The MyPeBS clinical study: for a new breast cancer screening strategy?
The aim of MyPeBS (MyPersonalBreast Cancer Screening) is to evaluate a breast cancer screening strategy based on individual risk. A total of 26 international partners are participating in MyPeBS. The clinical study is taking place in five countries (Belgium, France, Italy, the United Kingdom, Israel) and is coordinated by Unicancer (France). In Belgium it is being conducted at 10 hospitals and coordinated by the Jules Bordet Institute.
The limits of current screeningThe present programme of organized breast cancer screening (“Mammotest”) proposes the same screening for all women between the ages of 50 and 69 and takes just one risk factor into account: age. However, the cancer risk varies from one woman to another on the basis of other factors: family history, personal antecedents, lifestyle, genetic makeup. Although this screening is effective (less intensive treatment, reduced mortality), it has some disadvantages: over-diagnosis (the fact of finding and treating tumours that would not have posed a problem, at the rate of 1 in 5 of cancers detected), interval cancers (cancers not detected by screening, a quarter of cancers), false positives (women are recalled for further examinations that fail to reveal a cancer, between 2% and 10% of women screened).
MyPeBS, towards a personalised breast cancer screening
Today we are able to evaluate individual risk, in a standardised manner that is both reliable and reproducible. MyPeBS (MyPersonalBreast Cancer Screening) is the first European clinical study that aims to evaluate the benefits of personalised screening with a frequency and procedures adapted to the individual risk of each woman. This new screening strategy that takes into account individual risk aims to increase the effectiveness of organised cancer screening while reducing the disadvantages. The study results will make it possible to propose European recommendations to improve organised screening. For the study as a whole in the five “recruiter” countries, 85 000 women volunteers aged between 40 and 70 who have never had breast cancer are invited to participate. In Belgium, 10 screening centres, mostly in hospitals, are participating in the project. Prevention and Screening Clinic charged with coordination.
In practice, how to participate ?
- Administrative conditions for participating:
- to be a woman aged between 40 and 70 (inclusive)
- to have health cover and a social security number (N° NISS)
- to have a mobile phone and e-mail address
- Please note: this study is not for you if:
- you have a genetic mutation that places you at high risk of breast cancer (BRCA,…).
- you have already had breast cancer
- you have received irradiation of the chest wall (for a lymphoma)
- you have had an abnormal breast biopsy
- your last mammogram showed an abnormality that is being further investigated.
Do you meet the criteria? Do you want to participate in MyPeBS ?
lease view the short video below : Animation video presenting the MyPeBS study
- Please call the Jules Bordet Institute Screening Clinic which will be pleased to answer your questions and explain the procedure to follow:
- Tel : 02 541 30 53 or 02 541 30 54
- You can also call one of the Centres participating in MyPEBS.
- You can also consult the informed consent document that you will have to sign.
We thank you for your interest.
This project is financed by the European Union’s Horizon 2020 programme for research and innovation under grant agreement n° 755394. In Belgium it is also being supported by the Foundation against Cancer.