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 Articles scientifiques

Genomic aberrations in young and elderly  breast cancer patients.

Auteurs : Azim HA, Nguyen B, Brohée S, Zoppoli G, Sotiriou C
Année : 2015
Journal : BMC Med
Volume : 13
Pages : 266

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial.

Auteurs : Sonnenblick A, Brohée S, Fumagalli D, Rothé F, Vincent D, Ignatiadis M, Desmedt C, Salgado R, Sirtaine N, Loi S, Neven P, Loibl S, Denkert C, Joensuu H, Piccart-Gebhart M, Sotiriou C
Année : 2015
Journal : Oncotarget
Volume : 6
Pages : 30306-16

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome.

Auteurs : Fumagalli D, Gacquer D, Rothé F, Lefort A, Libert F, Brown D, Kheddoumi N, Shlien A, Konopka T, Salgado R, Larsimont D, Polyak K, Willard-Gallo K, Desmedt C, Piccart-Gebhart M, Abramowicz M, Campbell PJ, Sotiriou C, Detours V
Année : 2015
Journal : Cell Rep
Volume : 13
Pages : 277-89

Immunology and breast cancer: toward a new way of understanding breast cancer and developing novel therapeutic strategies.

Auteurs : Gingras I, Azim HA Jr, Ignatiadis M, Sotiriou C
Année : 2015
Journal : Clin Adv Hematol Oncol
Volume : 13
Pages : 372-82

St Gallen International Expert Consensus on the primary therapy of early breast cancer: an invaluable tool for physicians and scientists.

Auteurs : Ignatiadis M, Buyse M, Sotiriou C
Année : 2015
Journal : Ann Oncol
Volume : 26(8)
Pages : 1519-20

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

Auteurs : Van Keymeulen A, Lee MY, Ousset M, Brohée S, Rorive S, Giraddi RR, Wuidart A, Bouvencourt G, Dubois C, Salmon I, Sotiriou C, Phillips WA, Blanpain C
Année : 2015
Journal : Nature
Volume : 525(7567
Pages : 119-23

Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer.

Auteurs : Sonnenblick A, Brohée S, Fumagalli D, Vincent D, Venet D, Ignatiadis M, Salgado R, Van den Eynden G, Rothé F, Desmedt C, Neven P, Loibl S, Denkert C, Joensuu H, Loi S, Sirtaine N, Kellokumpu-Lehtinen PL, Piccart-Gebhart M, Sotiriou C
Année : 2015
Journal : BMC Med
Volume : 13(1)
Pages : 177

Evolving paradigms in multifocal breast cancer.

Auteurs : Salgado R, Aftimos P, Sotiriou C, Desmedt C
Année : 2015
Journal : Semin. Cancer Biol.
Volume : 31C
Pages : 111-118

Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

Auteurs : Yates LR, Gerstung M, Knappskog S, Desmedt C, Gundem G, Van Loo P, Aas T, Alexandrov LB, Larsimont D, Davies H, Li Y, Ju YS, Ramakrishna M, Haugland HK, Lilleng PK, Nik-Zainal S, McLaren S, Butler A, Martin S, Glodzik D, Menzies A, Raine K, Hinton J, Jones D, Mudie LJ, Jiang B, Vincent D, Greene-Colozzi A, Adnet PY, Fatima A, Maetens M, Ignatiadis M, Stratton MR, Sotiriou C, Richardson AL, Lønning PE, Wedge DC, Campbell PJ
Année : 2015
Journal : Nat. Med.
Volume : 21(7)
Pages : 751-9

Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial.

Auteurs : Salgado R, Denkert C, Campbell C, Savas P, Nucifero P, Aura C, de Azambuja E, Eidtmann H, Ellis CE, Baselga J, Piccart-Gebhart M, Michiels S, Bradbury I, Sotiriou C, Loi S
Année : 2015
Journal : JAMA Oncol
Volume : 1(4)
Pages : 448-54

Uncovering the genomic heterogeneity of multifocal breast cancer.

Auteurs : Desmedt C, Fumagalli D, Pietri E, Zoppoli G, Brown D, Nik-Zainal S, Gundem G, Rothé F, Majjaj S, Garuti A, Carminati E, Loi S, Van Brussel T, Boeckx B, Maetens M, Mudie L, Vincent D, Kheddoumi N, Serra L, Massa I, Ballestrero A, Amadori D, Salgado R, de Wind A, Lambrechts D, Piccart-Gebhart M, Larsimont D, Campbell PJ, Sotiriou C
Année : 2015
Journal : J. Pathol.
Volume : 236(4)
Pages : 457-66

New approaches for improving outcomes in breast cancer in Europe.

Auteurs : Di Leo A, Curigliano G, Diéras V, Malorni L, Sotiriou C, Swanton C, Thompson A, Tutt A, Piccart-Gebhart M
Année : 2015
Journal : Breast
Volume : 24(4)
Pages : 321-330

No significant viral transcription detected in whole breast cancer transcriptomes.

Auteurs : Fimereli D, Gacquer D, Fumagalli D, Salgado R, Rothé F, Larsimont D, Sotiriou C, Detours V
Année : 2015
Journal : BMC Cancer
Volume : 15(null)
Pages : 147

RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy.

Auteurs : Azim HA, Peccatori FA, Brohée S, Branstetter D, Loi S, Viale G, Piccart-Gebhart M, Dougall WC, Pruneri G, Sotiriou C
Année : 2015
Journal : Breast Cancer Res
Volume : 17
Pages : 24

PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2-Targeted Therapies in Breast Cancer.

Auteurs : Majewski IJ, Nuciforo P, Mittempergher L, Bosma AJ, Eidtmann H, Holmes E, Sotiriou C, Fumagalli D, Jimenez J, Aura C, Prudkin L, Díaz-Delgado MC, de la Peña L, Loi S, Ellis C, Schultz N, de Azambuja E, Harbeck N, Piccart-Gebhart M, Bernards R, Baselga J
Année : 2015
Journal : J. Clin. Oncol.
Volume : 33(12)
Pages : 1334-9

Optimising translational oncology in clinical practice: Strategies to accelerate progress in drug development.

Auteurs : Stahel R, Bogaerts J, Ciardiello F, De Ruysscher D, Dubsky P, Ducreux M, Finn S, Laurent-Puig P, Peters S, Piccart-Gebhart M, Smit E, Sotiriou C, Tejpar S, van Cutsem E, Tabernero J
Année : 2015
Journal : Cancer Treat Rev
Volume : 41(2)
Pages : 129-135

Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy With or Without Carboplatin in Human Epidermal Growth Factor Receptor 2-Positive and Triple-Negative Primary Breast Cancers.

Auteurs : Denkert C, Von Minckwitz G, Brase JC, Sinn BV, Gade S, Kronenwett R, Pfitzner BM, Salat C, Loi S, Schmitt WD, Schem C, Fisch K, Darb-Esfahani S, Mehta K, Sotiriou C, Wienert S, Klare P, André F, Klauschen F, Blohmer J, Krappmann K, Schmidt M, Tesch H, Kümmel S, Sinn P, Jackisch C, Dietel M, Reimer T, Untch M, Loibl S
Année : 2015
Journal : J. Clin. Oncol.
Volume : 33(9)
Pages : 983-91

Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology.

Auteurs : Fumagalli D, Blanchet-Cohen A, Brown D, Desmedt C, Gacquer D, Michiels S, Rothé F, Majjaj S, Salgado R, Larsimont D, Ignatiadis M, Maetens M, Piccart-Gebhart M, Detours V, Sotiriou C, Haibe-Kains B
Année : 2014
Journal : BMC Genomics
Volume : 15(1)
Pages : 1008

Deciphering clonality in aneuploid tumors using SNP array and sequencing data.

Auteurs : Lönnstedt IM, Caramia F, Li J, Fumagalli D, Salgado R, Rowan A, Salm M, Kanu N, Savas P, Horswell S, Gade S, Loibl S, Neven P, Sotiriou C, Swanton C, Loi S, Speed TP
Année : 2014
Journal : Genome Biol.
Volume : 15(9)
Pages : 470

Is the differentiation into molecular subtypes of breast cancer important for staging, local and systemic therapy, and follow up?

Auteurs : Sonnenblick A, Fumagalli D, Sotiriou C, Piccart-Gebhart M
Année : 2014
Journal : Cancer Treat Rev
Volume : 40(9)
Pages : 1089-95