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Breast Cancer Translational Research Laboratory J.C. Heuson

Description

The aim of the Institut Bordet J.-C. Heuson Breast Cancer Translational Research Laboratory (BCTL) is to facilitate the transfer of scientific discoveries about breast cancer that are made in the laboratory into clinical practice. It seeks to improve the molecular characterisation of breast cancer through the use of leading-edge technologies. A particular objective is to improve understanding of the biology of these cancers and of the mechanisms involved in resistance to treatment.

Research Projects

The various projects of the laboratory are funded by : Les Amis de l’Institut Bordet, FNRS, FNRS-Télévie, Fondation contre le Cancer, Breast Cancer Research Fondation (BCRF), Fonds Julie et Françoise Drion.
04/2021

Project 1

Characterization of endocrine resistant Luminal Breast Cancer using spatial transcriptomics AND epigenetic Analysis 
  • Project leader(s) : Christos Sotiriou, Françoise Rothé and Mattia Rediti
  • Collaborations : 
    • Dr François Fuks, Laboratory of Cancer Epigenetics, ULB-Cancer Research Center (U-CRC), Université libre de Bruxelles
    •  Prof Lundeberg at the SciLife laboratory, Stockholm, Sweden
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 2

MOLECULAR CHARACTERIZATION OF BREAST CANCER HETEROGENEITY USING SPATIAL TRANSCRIPTOMICS AND SINGLE CELL ANALYSIS
  • Project leader(s) : Christos Sotiriou, Françoise Rothé
  • Collaborations : 
    • Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 3

Tracking tumor evolution and distant recurrence in breast cancer by modeling tumor dormancy and the molecular clock rate

Project 4

Uncovering the immune landscape of breast cancer 

Project 5

INTERROGATING THE FUNCTIONAL RELEVANCE OF A-TO-I RNA EDITING IN BREAST CANCER

Our team

Head of BCTL
Prof Christos Sotiriou, MD PhD

Team
Françoise Rothé, PhD, Doctor of Sciences
Floriane Dupont, PhD Student (Biomedical Sciences)
Mattia Rediti, PhD Student (Biomedical Sciences)
Mariana Brandao, Research Fellow
Xiao Xiao Wang, PhD Student (Biomedical Sciences)
Andrea Joaquin Garcia, PhD Student (Bioinformatics)
David Venet, PhD, Post-Doc Bioinformatics
David Gacquer, Post-Doc Bioinformatics
Laurence Buisseret, PhD, Post-Doc Bioinformatics
Danai Fimereli, PhD, Post-Doc Bioinformatics
Samira Majjaj, Technician
Ghizlane Rouas, Technician
Delphine Vincent, Technician
Alfonsa Laragione, Technician
Matteo Serra, PhD Student (Bioinformatics)
Laetitia Collet, Medical fellow
Ismahene Mesnah, Phd Student
Frédérick Cailleux, PhD, Post-Doc
Andreas Papagiannis, Phd Student (Bioinformatics)

Administrative assistant
Loteda Hasku

12/04/2021

 Scientific publications

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer.

Authors : Chang CA, Jen J, Jiang S, Sayad A, Mer AS, Brown KR, Nixon AML, Dhabaria A, Tang KH, Venet D, Sotiriou C, Deng J, Wong KK, Adams S, Meyn P, Heguy A, Skok JA, Tsirigos A, Ueberheide B, Moffat J, Singh A, Haibe-Kains B, Khodadadi-Jamayran A, Neel BG
Year : 2022
Journal : Cancer Discov
Volume : 12
Pages : 1022-1045

Incorporation of TILs in daily breast cancer care: how much evidence can we bear?

Authors : Lænkholm AV, Callagy G, Balancin M, Bartlett JMS, Sotiriou C, Marchio C, Kok M, Dos Anjos CH, Salgado R
Year : 2022
Journal : Virchows Arch

Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer.

Authors : Loi S, Salgado R, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci MV, Badve S, Demaria S, Gray R, Munzone E, Drubay D, Lemonnier J, Sotiriou C, Kellokumpu-Lehtinen PL, Vingiani A, Gray K, André F, Denkert C, Piccart M, Roblin E, Michiels S
Year : 2022
Journal : NPJ Breast Cancer
Volume : 8
Pages : 3

Knowledge, Practice, and Attitudes of Physicians in Low- and Middle-Income Countries on Fertility and Pregnancy-Related Issues in Young Women With Breast Cancer.

Authors : Khan SZ, Arecco L, Villarreal-Garza C, Sirohi B, Ponde NF, Habeeb B, Brandão M, Azim HA Jr, Chowdhury AR, Bozovic-Spasojevic I, Kovalenko I, Odhiambo A, Seid FU, Mutombo AB, Petracci F, Vidra R, Altuna SC, Petrova M, Kourie HR, Ozturk MA, Razeti MG, Lengyel CG, Talibova N, Mariamidze E, Sacardo KP, Duma N, Gyawali B, Trapani D, Tagliamento M, Lambertini M
Year : 2022
Journal : JCO Glob Oncol
Volume : 8
Pages : e2100153

Author Correction: FDG positron emission tomography imaging and ctDNA detection as an early dynamic biomarker of everolimus efficacy in advanced luminal breast cancer.

Authors : Gombos A, Venet D, Ameye L, Vuylsteke P, Neven P, Richard V, Duhoux FP, Laes JF, Rothe F, Sotiriou C, Paesmans M, Awada A, Guiot T, Flamen P, Piccart-Gebhart M, Ignatiadis M, Gebhart G
Year : 2022
Journal : NPJ Breast Cancer
Volume : 8
Pages : 38