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Since its foundation, the Institut Jules Bordet has always strived to understand the cellular mechanisms involved in cancer and to improve cancer treatments. By collaborating closely with healthcare professionals and doctors from all fields of medicine, researchers at the Institut Bordet are able to offer patients the latest innovations derived from scientific research.

«The projects carried out by researchers at the Institut Bordet are exceptional in their cross-disciplinary nature and inventiveness. Driving healthcare forward and exploring all possible research avenues – this is the approach we take at the Institut Bordet. » 

Martine Piccart 
Research Director

How research helps to move cancer treatment forward

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At the Institut Jules Bordet, research is both clinical and translational. It is a highly organised activity mobilising and involving numerous health professionals, as well as patients.

Clinical Research

The term clinical research encompasses the studies and clinical trials that we carry out at the Institut Jules Bordet with our partners, academic research centres and pharmaceutical companies. The aims of these studies include:  

  • testing new diagnostic techniques;
  • comparing a number of different therapeutic strategies;
  • testing new and innovative medicines, particularly for cancers where no effective treatment currently exists.

Clinical research is only possible with patient involvement. Patient participation in clinical trials enables researchers to answer important research questions. 

Recherche Clinique

Translational Research

The principal roles of translational research are to understand cancer and identify markers that will assist in diagnosis, in predicting response to certain treatments and in patient prognosis. This type of research is based on the analysis of the blood and/or tumour samples that are removed, with the patient’s consent, during diagnosis or treatment. As an integral part of clinical research, the aim of translational research is to transform these findings rapidly into concrete options in the care offered to patients.

recherche translationnelle

Conducting and organising clinical research

The Institut Jules Bordet participates in cancer research by running clinical trials designed by its researchers and by other research groups across the world. A number of bodies are involved in the organisation and running of clinical trials:

Collaboration for innovation

Research is always a collaborative activity, particularly so in the field of cancer. In order to explore the most promising avenues, the Institut Jules Bordet works together with other academic and/or private bodies.

Academic Partners

Academic research is in the very DNA of the Institut Jules Bordet. Indeed, some prestigious research networks began their life here, including the EORTC, the BIG and, more recently the Oncodistinct network. Offering the best care for each patient is a complicated matter, given the complexity and diversity of their situations and the range of possible therapeutic strategies available. Therefore, medical staff need to question their practice rigorously, in particular by means of clinical trials. These trials take place in a university framework. Their results often have a significant and positive impact on the care offered to patients.

Private Partners

To find new drugs and new medical equipment for its patients, the Institut Jules Bordet supports and collaborates with those developing innovative treatments: pharmaceutical companies. Some clinical trials at the Institut Bordet are therefore carried out in partnership with these companies and always with the patient’s best interests in mind.

Taking part in the fight against cancer

Clinical Trials

As a patient, you may be invited to take part in a clinical trial of a new treatment, a new medical investigation technique or an innovative approach to care. In addition to the benefits this may bring you personally, taking part in a clinical trial contributes to the advancement of medicine and helps future patients.

However, your participation in these studies is strictly voluntary, not obligatory. No research procedures will ever be carried out without your agreement. To help you decide with full knowledge of the facts and give what is called “informed patient consent”, you will receive comprehensive information verbally and in writing. Your referring physician will explain to you as fully and clearly as possible the potential risks and benefits of taking part in the clinical trial you have been offered.

Your health and your quality of life are our primary concern. If your health requires it, or if you so choose, you may end your participation in the clinical trial at any time.

Choosing to participate in a clinical trial


Etudes cliniques

Find a clinical trial

Research & deontology

Professionals, join us in the fight against cancer!

 Scientific publications

External Validation of a Multiparametric Magnetic Resonance Imaging-based Nomogram for the Prediction of Extracapsular Extension and Seminal Vesicle Invasion in Prostate Cancer Patients Undergoing Radical Prostatectomy.

Authors : Diamand R, Ploussard G, Roumiguié M, Oderda M, Benamran D, Fiard G, Quackels T, Assenmacher G, Simone G, van Damme J, Malavaud B, Iselin C, Descotes JL, Roche JB, Peltier A, Roumeguère T, Albisinni S
Year : 2021
Journal : Eur Urol
Volume : 79
Pages : 180-185

Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer in the APHINITY Trial: 6 Years' Follow-Up.

Authors : Piccart-Gebhart M, Procter M, Fumagalli D, de Azambuja E, Clark E, Ewer MS, Restuccia E, Jerusalem G, Dent S, Reaby L, Bonnefoi H, Krop I, Liu TW, Pienkowski T, Toi M, Wilcken N, Andersson M, Im YH, Tseng LM, Lueck HJ, Colleoni M, Monturus E, Sicoe M, Guillaume S, Bines J, Gelber Rd, Viale G, Thomssen C
Year : 2021
Journal : J Clin Oncol
Volume : 39
Pages : 1448-1457

Stem Cell Transplantation for Diamond-Blackfan Anemia. A Retrospective Study on Behalf of the Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplantation Group (EBMT).

Authors : Miano M, Eikema DJ, de la Fuente J, Bosman P, Ghavamzadeh A, Smiers F, Sengeløv H, Yesilipek A, Formankova R, Bader P, Díaz Pérez MÁ, Bertrand Y, Niemeyer C, Diallo S, Ansari M, Bykova TA, Faraci M, Bonanomi S, Gozdzik J, Satti TM, Bodova I, Wölfl M, Rocha VG, Mellgren K, Rascon J, Holter W, Lange A, Meisel R, Beguin Y, Mozo Y, Kriván G, Sirvent A, Bruno B, Dalle JH, Onofrillo D, Giardino S, Risitano AM, de Latour RP, Dufour C
Year : 2021
Journal : Transplant Cell Ther
Volume : 27
Pages : 274.e1-274.e5

Gene expression signatures for tailoring adjuvant chemotherapy of luminal breast cancer: stronger evidence, greater trust.

Authors : Piccart-Gebhart M, Kalinsky K, Gray R, Barlow WE, Poncet C, Cardoso F, Winer E, Sparano J
Year : 2021
Journal : Ann Oncol
Volume : 32
Pages : 1077-1082

Assessment of potential process quality indicators for systemic treatment of breast cancer in Belgium: a population-based study.

Authors : van Walle L, Punie K, Van Eycken E, de Azambuja E, Wildiers H, Duhoux FP, Vuylsteke P, Barbeaux A, Van Damme N, Verhoeven D
Year : 2021
Journal : ESMO Open
Volume : 6
Pages : 100207