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Clinical Cellular Therapy Research Laboratory (LTCC)

Description

The Institut Bordet Clinical Cellular Therapy Research Laboratory (LTCC) is dedicated to fundamental and translational research in the fields of haematology and immunology cellular therapy.

The LTCC’s main objectives concern:

  • study of the interaction between leukaemic cells and their microenvironment;
  • establishment of new prognostic factors;
  • development of new therapeutic strategies.

Within the field of cellular therapy, the LTCC is studying the functional characterisation of mesenchymal stromal cells obtained from different tissues and their manipulation with a view to increasing their therapeutic potential.

Research projects

Project 1

IMPACT OF CHRONIC LYMPHOCYTIC LEUKEMIA-DERIVED EXTRACELLULAR VESICLES ON THE MICROENVIRONMENT IMMUNE LANDSCAPE / IMPACT DES VÉSICULES EXTRACELLULAIRES DÉRIVÉES DE LEUCÉMIE LYMPHOÏDE CHRONIQUE SUR LES CELLULES IMMUNITAIRES DU MICROENVIRONNEMENT

Project 2

Phenotypical Characterization and functional Impact of extracellular vesicles from mesenchymal stromal cells on Chronic Lymphocytic Leukemia B-cells

Project 3

Extracellular vesicles derived from umbilical cord-mesenchymal stromal cells for targeted therapy in pancreatic cancer

Project 4

Immunosuppressive microenvironment in multiple myeloma: role of bone marrow-mesenchymal cell (BM-MSC) glycosylation

Project 5

The use of Adipose Tissue derived Stromal Vascular Fraction in a Platelet-Rich Fibrin scaffold within Medication-Related Osteonecrosis of the Jaw treatment

Our team

Laboratory head
Laurence Lagneaux, PhD, Research Professor FNRS

The team
Basile Stamatopoulos, PhD, Professor
Karlien Pieters, laboratory technician
Nathan Dubois, PhD student Télévie
Cyril Bouland, MD, PhD student, FNRS
Achille Ruer, PhD student Télévie
David Van Morckoven, PhD student

24/11/2023

 Scientific publications

Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles as Natural Nanocarriers: Concise Review.

Authors : Draguet F, Bouland C, Dubois N, Bron D, Meuleman N, Stamatopoulos B, Lagneaux L
Year : 2023
Journal : Pharmaceutics
Volume : 15

Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases.

Authors : Bouhtit F, Najar M, Rahmani S, Melki R, Najimi M, Sadki K, Boukhatem N, Twizere JC, Meuleman N, Lewalle P, Lagneaux L, Merimi M
Year : 2022
Journal : Inflamm Res
Volume : 71
Pages : 887-898

Suburethral implantation of autologous regenerative cells for female stress urinary incontinence management: Results of a pilot study.

Authors : Maene A, Deniz G, Bouland C, Lagneaux L, Philippart P, Buxant F
Year : 2022
Journal : Eur J Obstet Gynecol Reprod Biol
Volume : 278
Pages : 38-44

Mesenchymal Stem/Stromal Cells as a Therapeutic Tool in Cell-Based Therapy and Regenerative Medicine: An Introduction Expertise to the Topical Collection.

Authors : Merimi M, Fahmi H, De Kock J, Beguin C, Burny A, Moll G, Poggi A, Najar M
Year : 2022
Journal : Cells
Volume : 11

Extracellular vesicle secretion by leukemia cells in vivo promotes CLL progression by hampering antitumor T-cell responses.

Authors : Gargiulo E, Viry E, Morande PE, Largeot A, Gonder S, Xian F, Ioannou N, Benzarti M, Kleine Borgmann FB, Mittelbronn M, Dittmar G, Nazarov PV, Meiser J, Stamatopoulos B, Ramsay AG, Moussay E, Paggetti J
Year : 2022
Journal : Blood Cancer Discov