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Clinical Cellular Therapy Research Laboratory (LTCC)

Description

The Institut Bordet Clinical Cellular Therapy Research Laboratory (LTCC) is dedicated to fundamental and translational research in the fields of haematology and immunology cellular therapy.

The LTCC’s main objectives concern:

  • study of the interaction between leukaemic cells and their microenvironment;
  • establishment of new prognostic factors;
  • development of new therapeutic strategies.

Within the field of cellular therapy, the LTCC is studying the functional characterisation of mesenchymal stromal cells obtained from different tissues and their manipulation with a view to increasing their therapeutic potential.

Research projects

Project 1

Discovering new altered signalling pathways leading to Richter syndrome in patients affected by chronic lymphoid leukaemia via whole genome sequencing.

Project 2

Phenotypical Characterization and functional Impact of extracellular vesicles from mesenchymal stromal cells on Chronic Lymphocytic Leukemia B-cells.

Project 3

Proteome, miRNome and immunobiological properties of mesenchymal stromal cells of different origins and of extracellular vesicles derived from these: influence of an inflammatory and infectious environment.
  • Collaborations :
    • Department of In Vitro Toxicology and Dermato-Cosmetology, Center for Pharmaceutical Research, VUB (De Kock J-Rogiers V)
    • Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Lebanon
    • Laboratory of Pediatric Hepatology and Cell Therapy, Institute of Experimental & Clinical Research, Université Catholique de Louvain, Brussels, Belgium (Pr E. Sokal, Dr M. Najimi)
  • Funding : FNRS-Télévie, Fonds Lambeau-Marteaux

Project 4

Chronic lymphoid leukaemia:
- Prognostic factors (cellular and molecular) of CLL
Role of microenvironment microvesicles
-
Predictive molecular markers for Richter transformation

Project 5

Medullary microenvironment
Immunomodulation by mesenchymal stem cells
  • Project leader : Medhi Najar (PhD)
  • Funding : Télévie, FNRS

Project 6

Medullary microenvironment
Differential potential of mesenchymal stem cells

Our team

Laboratory head
Laurence Lagneaux, PhD

The team
Basile Stamatopoulos, PhD
Medhi Najar, PhD
Emerence Crompot, PhD
Karlien Pieters, technologue de laboratoire

 Scientific publications

MicroRNA profiling and identification of let-7a as a target to prevent chemotherapy-induced primordial follicles apoptosis in mouse ovaries.

Authors : Alexandri C, Stamatopoulos B, Rothé F, Bareche Y, Devos M, Demeestere I
Year : 2019
Journal : Sci Rep
Volume : 9
Pages : 9636

Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials.

Authors : Wojdacz TK, Amarasinghe HE, Kadalayil L, Beattie A, Forster J, Blakemore SJ, Parker H, Bryant D, Larrayoz M, Clifford R, Robbe P, Davis ZA, Else M, Howard DR, Stamatopoulos B, Steele AJ, Rosenquist R, Collins A, Pettitt AR, Hillmen P, Plass C, Schuh A, Catovsky D, Oscier DG, Rose-Zerilli MJJ, Oakes CC, Strefford JC
Year : 2019
Journal : Blood Adv
Volume : 3
Pages : 2474-2481

Human Hepatocytes and Differentiated Adult-Derived Human Liver Stem/Progenitor Cells Display <i>In Vitro</i> Immunosuppressive Properties Mediated, at Least in Part, through the Nonclassical HLA Class I Molecule HLA-G.

Authors : Lombard CA, Sana G, LeMaoult J, Najar M, Ravau J, André F, Bouhtit F, Daouya M, Loustau M, Najimi M, Lagneaux L, Carosella ED, Sokal EM
Year : 2019
Journal : J Immunol Res
Volume : 2019
Pages : 8250584

The biological response of mesenchymal stromal cells to thymol and carvacrol in comparison to their essential oil: An innovative new study.

Authors : Bouhtit F, Najar M, Agha DM, Melki R, Najimi M, Sadki K, Lewalle P, Hamal A, Lagneaux L, Merimi M
Year : 2019
Journal : Food Chem Toxicol
Volume : 134
Pages : 110844

Mesenchymal stromal cells and natural killer cells: a complex story of love and hate.

Authors : Najar M, Fayyad-Kazan M, Merimi M, Burny A, Bron D, Fayyad-Kazan H, Meuleman N, Lagneaux L
Year : 2019
Journal : Curr Stem Cell Res Ther
Volume : 14(1)
Pages : 14-21