The Institut Bordet Clinical Haematology Department specialises in determining and treating diseases of the blood.
The Institut Bordet is committed to the treatment of these diseases and to offering patients high-quality, individual treatment.
In addition to the traditional approach to blood diseases, the Institut is also engaged in the development of innovative and complex techniques and therapies.
The Institut’s mission covers three main university fields: clinical, research and teaching.
The multidisciplinary nature of the Department, in both its diagnostic and therapeutic approaches, forms an integral part of all decisions concerning the patient.
The expertise of the Clinical Haematology Department includes the treatment of:
- high and low grade lymphoma
- multiple myeloma and associated conditions (POEMS syndrome, amyloidosis, etc)
- acute and chronic leukaemia
- myelodysplastic syndromes, myeloproliferative syndromes (Vaquez disease, essential thrombocytosis, myelofibrosis).
The Department has at its disposal all the modern technology needed to ensure the highest level of care:
- sterile isolation facilities for neutropenic patients following chemotherapy or after medullary aplasia of other origin
- stem cell transplant treatment
- development of new transplant techniques (non-myeloablative, T-cell depleted, haploidentical)
- cord blood bank for the ULB
- cytapheresis and photopheresis
- cell therapy.
In addition, in order to offer patients the most innovative treatments, the Department is involved in clinical research activities:
- in collaboration with the EORTC, LYSA, IFM and EBMT in the treatment of malignant haemopathies
- in collaboration with the EORTC in relation to associated infectious diseases
National and international approvals
- since 2006: "JACIE" for haematopoietic stem cell transplants in adults and children
- since 2012: Netcord/FACT accreditation for the cord blood bank
- since 2011: AFMPS for the "banking" of haematopoietic stem cells, cord blood and mesenchymatous cells.
The Department’s specific activities include:
- therapeutic photopheresis for Graft Versus Host Disease
- haploidentical transplants
- new cell immunotherapy protocols (TCAR)
- myeloma clinic comprising doctors (haematologist, radiologist, radiotherapist, surgeon, pain specialist) and paramedical staff (psychologist, dietician, nurse coordinator) specialising in the treatment of this disease.
- expertise in chronic lymphoid leukaemia for over 30 years in close collaboration with research laboratories (prognostic factors, microenvironment, new drug activity, etc) and in clinical research (clinical studies, access to new drugs)
- lymphoma: research in close collaboration with the French group LYSA
- acute leukaemia and myelodysplastic syndromes: international therapeutic protocols (EORTC, GRAALL, APL, etc)
Our commitment to teaching is at all levels of training: medical students, BioMed BACH3 students, oncology nurses, EHA Master Classes, GPs, doctors undergoing specialised training, paramedics and the general public.
The prognostic value of cognitive function, biomarkers of ageing and clinical factors in elderly patients with malignant haemopathy admitted for chemotherapy (Dominique Bron, MD, PhD)
- Project leader : Stéphanie Dubruille
- Collaborations : H. Wildiers, M. Delforge (KUL)
- Funding : Télévie, FNRS
Head of Department
Prof Dominique Bron – Haematological Medicine (lymphoma and chronic lymphoid leukaemia)
Heads of Clinic
- Prof Nathalie Meuleman - Haematological Medicine (Multiple myeloma and plasmocytary disorders, autografts)
- Prof Philippe Lewalle - Haematological Medicine (myeloproliferative syndrome, chronic myeloid leukaemia and allogeneic transplants)
- Prof Marie Maerevoet - Haematological Medicine (lymphomas and lymphoproliferative disorders, new drugs, autografts)
- Prof Sebastian Wittnebel - Haematological Medicine (leukaemia, myelodysplasia and allogeneic transplants)
- Dr Cécile Springael – Haematological Medicine (T lymphomas and rare lymphomas)
- Dr Phuong Huynh – General practitioner (ability of autologous and allogeneic donors to be collected in stem cells and lymphocytes, haemovigilance)
- Dr Marie Vercruyssen - Haematological Medicine (Multiple myeloma and plasmocytic disorders, autografts)
- Dr Chloé Spilleboudt - Haematological Medicine (Leukemias, Myelodysplasias and Allogeneic Transplantations)
- Dr Adriano Salaroli - Haematological Medicine (Myeloproliferative syndromes, Chronic Myeloid Leukemia, Leukemia, Myelodysplasia and Allogeneic Transplantation)
Head Nursing (Tel : +32 (0)2 541 33 55)
- Patrick Crombez
Nursing «coordinator of allografts » (Tel : +32 (0)2 541 33 30)
- Marie-France Jaivenois
Nurses (health care coordinators) (Tel : +32 (0)2 541 73 94)
- Sophie Delaunois
- Zilfi Balci
Cytapheresis unit and Stem Cell Collection (Tel : +32 (0)2 541 32 11)
- Philippe Lewalle – Responsible physician
- Adriano Salaroli – Resident
- Corine Mal – Nurse
- Walter Bellemans – Nurse
- Munteanu Nicoleta – Nurse
- Olivier Mugema - Nurse
Transplantation Coordination (Tel : +32 (0)2 541 32 12)
- Sandra Michiels – Coordinator
- Redouane Rouas – Suppleant
Data Managing Unit
- Anne De Meuter – Head Nurse (Tel : +32 (0)2 541 72 05)
- Dominique De Poorter – Nurse (Tel : +32 (0)2 541 35 98)
- Sabrina Costantini – Administrative (Tel : +32 (0)2 541 37 55)
- Delphine Leva – Administrative (Tel : +32 (0)2 541 33 57)
- Gregory Rios – Nurse (Tel : +32 (0)2 541 36 47)
- Aurélie Timmermans (Tel +32 (0)2 541 72 25)
- Sabine Ackermans (administration) - Tel : +32 (0)2 541 37 28
- Jennifer Marinus (consultation) - Tel : +32 (0)2 541 36 84
Mesenchymal stromal cells and natural killer cells: a complex story of love and hate.
Authors : Najar M, Fayyad-Kazan M, Merimi M, Burny A, Bron D, Fayyad-Kazan H, Meuleman N, Lagneaux L
Year : 2019
Journal : Curr Stem Cell Res Ther
Volume : 14(1)
Pages : 14-21
Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.
Authors : Loi S, Drubay D, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci MV, Badve S, Demaria S, Gray R, Munzone E, Lemonnier J, Sotiriou C, Piccart-Gebhart M, Kellokumpu-Lehtinen PL, Vingiani A, Gray K, Andre F, Denkert C, Salgado R, Michiels S
Year : 2019
Journal : J Clin Oncol
Pages : JCO1801010
Reciprocal immuno-biological alterations occur during the co-culture of natural killer cells and adipose tissue-derived mesenchymal stromal cells.
Authors : Najar M, Fayyad-Kazan M, Merimi M, Meuleman N, Bron D, Fayyad-Kazan H, Lagneaux L
Year : 2019
Journal : Cytotechnology
Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres.
Authors : Poirel HA, Vanspauwen M, Macq G, De Geyndt A, Maertens J, Willems E, Selleslag D, Poiré X, Theunissen K, Graux C, Kerre T, Zachée P, Meuleman N, De Becker A, Verlinden A, Van Obbergh F, Schuermans C, de Wilde V, Jaspers A, Pranger D, Deeren D, van Riet I, Vaes E, Beguin Y
Year : 2019
Journal : Bone Marrow Transplant
Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients.
Authors : Chi VLD, Garaud S, De Silva P, Thibaud V, Stamatopoulos B, Berehad M, Gu-Trantien C, Krayem M, Duvillier H, Lodewyckx JN, Willard-Gallo K, Sibille C, Bron D
Year : 2019
Journal : BMC Cancer
Volume : 19
Pages : 81