The aim of the Institut Bordet J.-C. Heuson Breast Cancer Translational Research Laboratory (BCTL) is to facilitate the transfer of scientific discoveries about breast cancer that are made in the laboratory into clinical practice. It seeks to improve the molecular characterisation of breast cancer through the use of leading-edge technologies. A particular objective is to improve understanding of the biology of these cancers and of the mechanisms involved in resistance to treatment.
The principal objective of research at the BCTL is to improve our understanding of the biology of breast cancer and of the propagation and progression of the disease at a molecular level by using leading-edge technologies such as high throughput DNA sequencing. The Laboratory has developed a number of prognostic and predictive gene signatures, notably the Genomic Grade Index (GGI). This Index makes it possible to classify patients into different prognostic groups and to identify which of them will derive significant benefit from chemotherapy or hormone therapy.
Professor Sotiriou’s team is also studying the molecular heterogeneity of breast cancer, from the viewpoint of both inter- and intra-patient variability, and is seeking to identify the mechanisms associated with sensitivity and resistance to treatment.
Alongside this, the team is developing a number of research projects involving liquid biopsies, in particular the characterisation of tumour DNA circulating in the bloodstream. This tool is promising for the monitoring of cancerous disease, the early detection of recurrence and the evaluation of response/resistance to a treatment. The results of this research should offer new prospects for the therapeutic treatment of patients affected by breast cancer.
The BCTL is involved in training students from the ULB Faculty of Medicine and Biomedical Sciences. In particular, each year we welcome students in the process of completing their final dissertation. We also supervise students completing their doctoral thesis in Biomedical Sciences (4 to 6 students over a 4-year period).
Research Projects
Project 1
Genomic characterization of endocrine resistant metastatic lobular breast cancer
- Project leader : Christos Sotiriou et Christine Desmedt
- Collaborations :
- Dr Diether Lambrechts, Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Belgium; Vesalius Research Center, VIB, Leuven, Belgium
- Dr Giancarlo Pruneri, Division of Pathology, European Institute of Oncology, Milan, Italy
- Dr Patrick Neven, University Hospitals Leuven, Gynecology and Obstetrics, Multidisciplinary Breast Centre, Oncology, KU Leuven, Leuven, Belgium
- Dr Elia Biganzoli, Unit of Medical Statistics, Department of Clinical Sciences and Community Health, University of Milan Campus Cascina Rosa, Milan, Italy - Funding : Les Amis de l'Institut Bordet,Fondation Contre le Cancer, Fondation Suzan G. Komen
Project 2
Molecular characterization of triple-negative breast cancer and rare histotypes
- Project leader : Christos Sotiriou et Françoise Rothé
- Collaborations :
- International Breast Cancer Study Group (IBCSG)
- BRussels Interuniversity Genomics High Throughput core (BRIGHTcore) - Funding : Les Amis de l'Institut Bordet, Fonds National de la Recherche Scientifique (FNRS - Télévie), Breast Cancer Research Foundation (BCRF)
Project 3
Interrogating the use of liquid biopsy to evaluate breast cancer progression
- Project leader : Christos Sotiriou et Françoise Rothé
- Collaborations : Dr Philippe Bedard, Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre, Toronto
- Funding : Fonds National de la Recherche Scientifique (FNRS)
Project 4
Impact of elevated patient’s body mass index (BMI) on BC dormancy and biology
- Project leader : Christos Sotiriou et Christine Desmedt
- Collaborations :Dr Elia Biganzoli, Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, Université de Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Project 5
Elucidating the effect of pregnancy on breast cancer biology
- Project leader : Christos Sotiriou et Françoise Rothé
- Collaborations :
- Prof Elaine Mardis, McDonnell Genome Institute, Washington University
- Prof Viale et Dr Pruneri, Istituto Europeo di Oncologia, Milan - Funding : Fonds National de la Recherche Scientifique (FNRS - Télévie), Breast Cancer Research Foundation (BCRF)
Project 6
Interrogating the functional relevance of A-to-I RNA editing in breast cancer
- Project leader : Christos Sotiriou et Françoise Rothé
- Collaborations : Prof. Vincent Detours, IRIBHM, ULB
- Funding : Fonds National de la Recherche Scientifique (FNRS - Télévie)
Our team
Laboratory Director
Professor Christos Sotiriou, MD PhD
Researchers
Christine Desmedt, PhD
David Venet, PhD
François Richard, PhD
Françoise Rothé, PhD
Marion Maetens, PhD
PhD students
Bastien Nguyen
David Norman Brown
Floriane Dupont
Laurence Buisseret
Vinu Jose
Yacine Bareche
Laboratory Technologists
Delphine Vincent
Ghizlane Rouas
Naïma Kheddoumi
Samira Majjaj
Administrative Assistance
Dominique Roels
Jeanne Letor
Scientific publications
Immunity drives <i>TET1</i> regulation in cancer through NF-?B.
Authors : Collignon E, Canale A, Al Wardi C, Bizet M, Calonne E, Dedeurwaerder S, Garaud S, Naveaux C, Barham W, Wilson A, Bouchat S, Hubert P, Van Lint C, Yull F, Sotiriou C, Willard-Gallo K, Noel A, Fuks F
Year : 2018
Journal : Sci Adv
Volume : 4
Pages : eaap7309
Scoring of tumor-infiltrating lymphocytes: from visual estimation to machine learning.
Authors : Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C
Year : 2018
Journal : Semin Cancer Biol
Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations.
Authors : Nguyen B, Venet D, Azim HA Jr, Brown D, Desmedt C, Lambertini M, Majjaj S, Pruneri G, Peccatori F, Piccart M, Rothé F, Sotiriou C
Year : 2018
Journal : NPJ Breast Cancer
Volume : 4
Pages : 23
The BCY3/BCC 2017 survey on physicians' knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients.
Authors : Lambertini M, Di Maio M, Pagani O, Curigliano G, Poggio F, Del Mastro L, Paluch-Shimon S, Loibl S, Partridge AH, Demeestere I, Azim HA Jr, Peccatori FA
Year : 2018
Journal : Breast
Volume : 42
Pages : 41-49
Feasibility of developing reliable gene expression modules from FFPE derived RNA profiled on Affymetrix arrays.
Authors : Jose V, Fumagalli D, Rothé F, Majjaj S, Loi S, Michiels S, Sotiriou C
Year : 2018
Journal : 0
Volume : 13
Pages : e0203346
