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Breast Cancer Translational Research Laboratory J.C. Heuson

Description

The aim of the Institut Bordet J.-C. Heuson Breast Cancer Translational Research Laboratory (BCTL) is to facilitate the transfer of scientific discoveries about breast cancer that are made in the laboratory into clinical practice. It seeks to improve the molecular characterisation of breast cancer through the use of leading-edge technologies. A particular objective is to improve understanding of the biology of these cancers and of the mechanisms involved in resistance to treatment.

Research Projects

The various projects of the laboratory are funded by : Les Amis de l’Institut Bordet, FNRS, FNRS-Télévie, Fondation contre le Cancer, Breast Cancer Research Fondation (BCRF), Fonds Julie et Françoise Drion.

Project 1

Characterization of endocrine resistant Luminal Breast Cancer using spatial transcriptomics AND epigenetic Analysis 
  • Project leader(s) : Christos Sotiriou, Françoise Rothé and Mattia Rediti
  • Collaborations : 
    • Dr François Fuks, Laboratory of Cancer Epigenetics, ULB-Cancer Research Center (U-CRC), Université libre de Bruxelles
    •  Prof Lundeberg at the SciLife laboratory, Stockholm, Sweden
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 2

Molecular characterization of triple-negative breast cancer using spatial transcriptomics and single cell analysis.
  • Project leader(s) : Christos Sotiriou, Françoise Rothé
  • Collaborations : 
    • Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 3

Tracking tumor evolution and distant recurrence in breast cancer by modeling tumor dormancy and the molecular clock rate

Project 4

Uncovering the immune landscape of breast cancer 

Project 5

INTERROGATING THE FUNCTIONAL RELEVANCE OF A-TO-I RNA EDITING IN BREAST CANCER

Our team

Head of BCTL
Prof Christos Sotiriou, MD PhD

Team
Françoise Rothé, PhD, Doctor of Sciences
Floriane Dupont, PhD Student (Biomedical Sciences)
Mattia Rediti, PhD Student (Biomedical Sciences)
Mariana Brandao, Research Fellow
XiaoXiao, PhD Student (Biomedical Sciences)
Andrea Joaquin Garcia, PhD Student (Bioinformatics)
David Venet, PhD, Post-Doc Bioinformatics
David Gacquer, Post-Doc Bioinformatics
Laurence Buisseret, PhD, Post-Doc Bioinformatics
Danai Fimereli, PhD, Post-Doc Bioinformatics
Samira Majjaj, Technician
Ghizlane Rouas, Technician
Delphine Vincent, Technician
Alfonsa Laragione, Technician

Administrative assistant
Julie Noël

15/01/2020

 Scientific publications

Lessons learned at SABCS 2019 and to-dos from immunotherapy in breast cancer.

Authors : Eiger D, Brandão M, de Azambuja E
Year : 2020
Journal : ESMO Open
Volume : 5

A Microfluidic Ion Sensor Array.

Authors : Wu C, Selberg J, Nguyen B, Pansodtee P, Jia M, Dechiraju H, Teodorescu M, Rolandi M
Year : 2020
Journal : Small
Pages : e1906436

Computed tomography-based analyses of baseline body composition parameters and changes in breast cancer patients under treatment with CDK 4/6 inhibitors.

Authors : Franzoi MA, Vandeputte C, Eiger D, Caparica R, Brandão M, de Angelis C, Hendlisz A, Awada A, Piccart-Gebhart M, de Azambuja E
Year : 2020
Journal : Breast Cancer Res Treat

Anticoagulant therapies and outcomes in obese patients with acute venous thromboembolism.

Authors : Quan S, Smith J, Wu C, Koshman SL, Nguyen B, Bungard TJ
Year : 2020
Journal : Thromb Res
Volume : 187
Pages : 56-62

Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families.

Authors : Van Marcke C, Helaers R, De Leener A, Merhi A, Schoonjans CA, Ambroise J, Galant C, Delrée P, Rothé F, Bar I, Khoury E, Brouillard P, Canon JL, Vuylsteke P, Machiels JP, Berlière M, Limaye N, Vikkula M, Duhoux FP
Year : 2020
Journal : Breast Cancer Res
Volume : 22
Pages : 36