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Breast Cancer Translational Research Laboratory J.C. Heuson

Description

The aim of the Institut Bordet J.-C. Heuson Breast Cancer Translational Research Laboratory (BCTL) is to facilitate the transfer of scientific discoveries about breast cancer that are made in the laboratory into clinical practice. It seeks to improve the molecular characterisation of breast cancer through the use of leading-edge technologies. A particular objective is to improve understanding of the biology of these cancers and of the mechanisms involved in resistance to treatment.

Research Projects

The various projects of the laboratory are funded by : Les Amis de l’Institut Bordet, FNRS, FNRS-Télévie, Fondation contre le Cancer, Breast Cancer Research Fondation (BCRF), Fonds Julie et Françoise Drion.

Project 1

Characterization of endocrine resistant Luminal Breast Cancer using spatial transcriptomics AND epigenetic Analysis 
  • Project leader(s) : Christos Sotiriou, Françoise Rothé and Mattia Rediti
  • Collaborations : 
    • Dr François Fuks, Laboratory of Cancer Epigenetics, ULB-Cancer Research Center (U-CRC), Université libre de Bruxelles
    •  Prof Lundeberg at the SciLife laboratory, Stockholm, Sweden
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 2

Molecular characterization of triple-negative breast cancer using spatial transcriptomics and single cell analysis.
  • Project leader(s) : Christos Sotiriou, Françoise Rothé
  • Collaborations : 
    • Prof. Lundeberg at the SciLife laboratory (Stockholm, Sweden)
    • Dr Frédérick Libert, ULB/VUB Brightcore sequencing facility

Project 3

Tracking tumor evolution and distant recurrence in breast cancer by modeling tumor dormancy and the molecular clock rate

Project 4

Uncovering the immune landscape of breast cancer 

Project 5

INTERROGATING THE FUNCTIONAL RELEVANCE OF A-TO-I RNA EDITING IN BREAST CANCER

Our team

Head of BCTL
Prof Christos Sotiriou, MD PhD

Team
Françoise Rothé, PhD, Doctor of Sciences
Floriane Dupont, PhD Student (Biomedical Sciences)
Mattia Rediti, PhD Student (Biomedical Sciences)
Mariana Brandao, Research Fellow
XiaoXiao, PhD Student (Biomedical Sciences)
Andrea Joaquin Garcia, PhD Student (Bioinformatics)
David Venet, PhD, Post-Doc Bioinformatics
David Gacquer, Post-Doc Bioinformatics
Laurence Buisseret, PhD, Post-Doc Bioinformatics
Danai Fimereli, PhD, Post-Doc Bioinformatics
Samira Majjaj, Technician
Ghizlane Rouas, Technician
Delphine Vincent, Technician
Alfonsa Laragione, Technician

Administrative assistant
Julie Noël

 Scientific publications

Lucitanib for the Treatment of HR<sup>+</sup>/HER2<sup>-</sup> Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study.

Authors : Hui R, Pearson A, Cortes J, Campbell C, Poirot C, Azim HA Jr, Fumagalli D, Lambertini M, Daly F, Arahmani A, Perez-Garcia J, Aftimos P, Bedard PL, Xuereb L, Scheepers ED, Vicente M, Goulioti T, Loibl S, Loi S, Pierrat MJ, Turner NC, Andre F, Curigliano G
Year : 2020
Journal : Clin Cancer Res
Volume : 26
Pages : 354-363

Reactive stroma and trastuzumab resistance in HER2-positive early breast cancer.

Authors : Sonnenblick A, Salmon-Divon M, Salgado R, Dvash E, Pondé N, Zahavi T, Salmon A, Loibl S, Denkert C, Joensuu H, Ameye L, Van den Eynden G, Kellokumpu-Lehtinen PL, Azaria A, Loi S, Michiels S, Richard F, Sotiriou C
Year : 2020
Journal : Int J Cancer

The 2019 WHO classification of tumours of the breast.

Authors : Hoon Tan P, Ellis I, Allison K, Brogi E, Fox SB, Lakhani S, Lazar AJ, Morris EA, Sahin A, Salgado R, Sapino A, Sasano H, Schnitt S, Sotiriou C, van Diest P, White VA, Lokuhetty D, Cree IA
Year : 2020
Journal : Histopathology

Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer.

Authors : Nguyen B, Venet D, Lambertini M, Desmedt C, Salgado R, Horlings HM, Rothé F, Sotiriou C
Year : 2019
Journal : Breast Cancer Res
Volume : 21
Pages : 25

Correction: HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2.

Authors : Hanker AB, Garrett JT, Estrada MV, Moore PD, Ericsson PG, Koch JP, Langley E, Singh S, Kim PS, Frampton GM, Sanford E, Owens P, Becker J, Groseclose MR, Castellino S, Joensuu H, Huober J, Brase JC, Majjaj S, Brohée S, Venet D, Brown D, Baselga J, Piccart-Gebhart M, Sotiriou C, Arteaga CL
Year : 2019
Journal : Clin Cancer Res
Volume : 25
Pages : 1434