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Breast Cancer Translational Research Laboratory J.C. Heuson

Description

The aim of the Institut Bordet J.-C. Heuson Breast Cancer Translational Research Laboratory (BCTL) is to facilitate the transfer of scientific discoveries about breast cancer that are made in the laboratory into clinical practice. It seeks to improve the molecular characterisation of breast cancer through the use of leading-edge technologies. A particular objective is to improve understanding of the biology of these cancers and of the mechanisms involved in resistance to treatment.

Research Projects

Project 1

Genomic characterization of endocrine resistant metastatic lobular breast cancer
  • Project leader : Christos Sotiriou et Christine Desmedt
  • Collaborations : 
    Dr Diether Lambrechts, Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Belgium; Vesalius Research Center, VIB, Leuven, Belgium
    Dr Giancarlo Pruneri, Division of Pathology, European Institute of Oncology, Milan, Italy
    Dr Patrick Neven, University Hospitals Leuven, Gynecology and Obstetrics, Multidisciplinary Breast Centre, Oncology, KU Leuven, Leuven, Belgium
    Dr Elia Biganzoli, Unit of Medical Statistics, Department of Clinical Sciences and Community Health, University of Milan Campus Cascina Rosa, Milan, Italy
  • Funding : Les Amis de l'Institut Bordet,Fondation Contre le Cancer, Fondation Suzan G. Komen

Project 2

Molecular characterization of triple-negative breast cancer and rare histotypes
  • Project leader : Christos Sotiriou et Françoise Rothé
  • Collaborations :
    - International Breast Cancer Study Group (IBCSG)
    - BRussels Interuniversity Genomics High Throughput core (BRIGHTcore)
  • Funding : Les Amis de l'Institut Bordet,  Fonds National de la Recherche Scientifique (FNRS - Télévie), Breast Cancer Research Foundation (BCRF)

Project 3

Interrogating the use of liquid biopsy to evaluate breast cancer progression
  • Project leader : Christos Sotiriou et Françoise Rothé
  • Collaborations : Dr Philippe Bedard, Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre, Toronto
  • Funding : Fonds National de la Recherche Scientifique (FNRS)

Project 4

Impact of elevated patient’s body mass index (BMI) on BC dormancy and biology
  • Project leader : Christos Sotiriou et Christine Desmedt
  • Collaborations :Dr Elia Biganzoli, Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, Université de Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Project 5

Elucidating the effect of pregnancy on breast cancer biology
  • Project leader :  Christos Sotiriou et Françoise Rothé
  • Collaborations : 
    Prof Elaine Mardis, McDonnell Genome Institute, Washington University
    Prof Viale et Dr Pruneri, Istituto Europeo di Oncologia, Milan
  • Funding : Fonds National de la Recherche Scientifique (FNRS - Télévie), Breast Cancer Research Foundation (BCRF)

Project 6

Interrogating the functional relevance of A-to-I RNA editing in breast cancer
  • Project leader :  Christos Sotiriou et Françoise Rothé
  • Collaborations : Prof. Vincent Detours, IRIBHM, ULB
  • Funding : Fonds National de la Recherche Scientifique (FNRS - Télévie)

Our team

Laboratory Director
Professor Christos Sotiriou, MD PhD

Researchers
Christine Desmedt, PhD
David Venet, PhD
François Richard, PhD
Françoise Rothé, PhD
Marion Maetens, PhD

PhD students
Bastien Nguyen
David Norman Brown
Floriane Dupont
Laurence Buisseret
Vinu Jose
Yacine Bareche

Laboratory Technologists
Delphine Vincent
Ghizlane Rouas
Naïma Kheddoumi
Samira Majjaj

Administrative Assistance
Dominique Roels
Jeanne Letor

 Scientific publications

Immunity drives <i>TET1</i> regulation in cancer through NF-?B.

Authors : Collignon E, Canale A, Al Wardi C, Bizet M, Calonne E, Dedeurwaerder S, Garaud S, Naveaux C, Barham W, Wilson A, Bouchat S, Hubert P, Van Lint C, Yull F, Sotiriou C, Willard-Gallo K, Noel A, Fuks F
Year : 2018
Journal : Sci Adv
Volume : 4
Pages : eaap7309

Scoring of tumor-infiltrating lymphocytes: from visual estimation to machine learning.

Authors : Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C
Year : 2018
Journal : Semin Cancer Biol

Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations.

Authors : Nguyen B, Venet D, Azim HA Jr, Brown D, Desmedt C, Lambertini M, Majjaj S, Pruneri G, Peccatori F, Piccart M, Rothé F, Sotiriou C
Year : 2018
Journal : NPJ Breast Cancer
Volume : 4
Pages : 23

The BCY3/BCC 2017 survey on physicians' knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients.

Authors : Lambertini M, Di Maio M, Pagani O, Curigliano G, Poggio F, Del Mastro L, Paluch-Shimon S, Loibl S, Partridge AH, Demeestere I, Azim HA Jr, Peccatori FA
Year : 2018
Journal : Breast
Volume : 42
Pages : 41-49

Feasibility of developing reliable gene expression modules from FFPE derived RNA profiled on Affymetrix arrays.

Authors : Jose V, Fumagalli D, Rothé F, Majjaj S, Loi S, Michiels S, Sotiriou C
Year : 2018
Journal : 0
Volume : 13
Pages : e0203346

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