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Anatomical pathology department

The Anatomical Pathology Department is responsible for analysing tumours sent to it by the Institut Jules Bordet, the CHU St-Pierre and the Ixelles and Molière IRIS SUD hospitals. It is a reference centre in various fields, including the diagnosis of breast, gynaecological, digestive, urogenital, pulmonary, soft tissue and head and neck cancers and lymphomas.

The Department analyses:

  • operative specimens removed during surgical procedures
  • biopsies
  • cytological samples (smears, etc)
  • blood samples for specific cytogenetic examinations (traditional karyotypes for the diagnosis and monitoring of leukaemia and molecular genetic techniques in order to provide prognostic factors).

The Department operates to the ISO 15189 standard.

Research projects

The Anatomical Pathology Department actively collaborates with research teams at the Institut Bordet as part of translational research. In addition, numerous multicentre clinical studies (EORTC, BIG, etc) are coordinated from an anatomopathological viewpoint by the Department which has thus become a central reference laboratory. We are also conducting more specific projects, including:

  

Project 1

Optimisation of preanalytic stages for sequencing. Influence of the preanalytic stage on the detection of gene mutations via next-generation sequencing (NGS).

Project 2

Quality control by infrared spectroscopy. Analysis of the quality and preservation (stability) of proteins from tumour bank frozen samples by infrared spectroscopy.

Project 3

Liquid biopsies. Tumour bank extension to blood/plasma samples thanks to the funding of plasma stabilising tubes by Les Amis de l’IJB. Qualitative and quantitative analysis of tumour DNA in plasma.

Project 4

Analysis of intra- and peritumoral inflammatory infiltrate in patients who have undergone surgery for hepatocellular carcinoma after intra-arterial radio-embolization. 

Project 5

CEA and ctDNA, post-surgery prognostic factors of primary and hepatic metastatic colorectal cancers.

Updating : 04/2021

Our team

Pathologists
- Pr D. Larsimont, (Head of Department)
  Tel : + 32 (0)2 541 31 15
- Dr M. Chintinne (Molecular Biology and Sequencing)
  Tel : + 32 (0)2 541 33 13
- Dr N. de Saint Aubain (immunohistochemistry)
  Tel :+ 32 (0)2 541 31 19
- Dr R. de Wind (Cytology)
  Tel :+ 32 (0)2 541 30 34
- Dr D. d’Olne, Consultant
  Tel :+ 32 (0)2 541 33 13
- Dr M. Gomez Galdon (Macroscopy)
  Tel :+ 32 (0)2 541 33 13
- Dr P. Heimann (Cytogenetic)
  Tel :+ 32 (0)2 541 31 44
- Dr N. Sirtaine (Histology)
  Tel :+ 32 (0)2 541 31 19
- Prof. P. Demetter (Head of Clinic)
  Tel : + 32 (0)2 541 36 98
- Dr L. Verset (Head of Clinic ajunct)
  Tel : + 32 (0)2 541 33 13
- Dr F. Lifrange, PG
  Tel :+ 32 (0)2 541 34 93

Secretariat 
- Permanence (Tel : + 32 (0)2 541 73 23)
- Joëlle Vanderheyde, Secretary
  Tel : + 32 (0)2 541 31 05

Quality Cell
- Ioanna Laïos  
  Tel : + 32 (0)2 541 73 10

Clinical Studies
- Dr Sc L. Craciun, Coordinator
  Tel :+ 32 (0)2 541 72 16

Tumour bank
Dr Sc L. Craciun, Coordinator
A. Spinette

09/04/2021

 Scientific publications

Absence of residual fluorescence in the surgical bed at near-infrared fluorescence imaging predicts negative margins at final pathology in patients treated with breast-conserving surgery for breast cancer.

Authors : Pop FC, Veys I, Vankerckhove S, Barbieux R, Chintinne M, Moreau M, Donckier V, Larsimont D, Bourgeois P, Liberale G
Year : 2021
Journal : Eur J Surg Oncol
Volume : 47
Pages : 269-275

Rationale and design of REGINA, a phase II trial of neoadjuvant regorafenib, nivolumab, and short-course radiotherapy in stage II and III rectal cancer.

Authors : Bregni G, Vandeputte C, Pretta A, Senti C, Trevisi E, Acedo Reina E, Kehagias P, Liberale G, Moretti L, Bali MA, Demetter P, Flamen P, Carrasco J, DHondt L, Geboes K, Gokburun Y, Peeters M, Van den Eynde M, Van Laethem JL, Vergauwe P, Chapot CA, Buyse M, Deleporte A, Hendlisz A, Sclafani F
Year : 2021
Journal : Acta oncologica
Pages : 1-5

Implementation of colonoscopy quality monitoring in a Belgian university hospital with integrated computer-based extraction of adenoma detection rate.

Authors : Ouazzani S, Lemmers A, Martinez F, Kindt R, Le Moine O, Delhaye M, Arvanitakis M, Demetter P, Devière J, Eisendrath P
Year : 2021
Journal : Endosc Int Open
Volume : 9
Pages : E197-E202

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Authors : Demetter P, Maréchal R, Puleo F, Delhaye M, Debroux S, Charara F, Gomez Galdon M, Van Laethem JL, Verset L
Year : 2021
Journal : Front Oncol
Volume : 11
Pages : 630086

Clinico-metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases.

Authors : Bohlok A, Duran Derijckere I, Azema H, Lucidi V, Vankerckhove S, Hendlisz A, Van Laethem JL, Vierasu I, Goldman S, Flamen P, Larsimont D, Demetter P, Dirix L, Vermeulen P, Donckier V
Year : 2021
Journal : J Surg Oncol