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Anatomical pathology department

The Anatomical Pathology Department is responsible for analysing tumours sent to it by the Institut Jules Bordet, the CHU St-Pierre and the Ixelles and Molière IRIS SUD hospitals. It is a reference centre in various fields, including the diagnosis of breast, gynaecological, digestive, urogenital, pulmonary, soft tissue and head and neck cancers and lymphomas.

The Department analyses:

  • operative specimens removed during surgical procedures
  • biopsies
  • cytological samples (smears, etc)
  • blood samples for specific cytogenetic examinations (traditional karyotypes for the diagnosis and monitoring of leukaemia and molecular genetic techniques in order to provide prognostic factors).

The Department operates to the ISO 15189 standard.

Research projects

The Anatomical Pathology Department actively collaborates with research teams at the Institut Bordet as part of translational research. In addition, numerous multicentre clinical studies (EORTC, BIG, etc) are coordinated from an anatomopathological viewpoint by the Department which has thus become a central reference laboratory. We are also conducting more specific projects, including:

  

Project 1

Optimisation of preanalytic stages for sequencing. Influence of the preanalytic stage on the detection of gene mutations via next-generation sequencing (NGS).

Project 2

Digital imaging analysis evaluation of proliferation markers Ki67, MCM2 and Geminin in breast cancer in the Anatomical Pathology Department’s Genomic Grade cohort.
  • Project leader : Denis Larsimont,
  • Collaboration : Vincent Detour, ULB
  • Funding : Fonds Lambeau-Marteaux

Project 3

Quality control by infrared spectroscopy. Analysis of the quality and preservation (stability) of proteins from tumour bank frozen samples by infrared spectroscopy.

Project 4

Liquid biopsies. Tumour bank extension to blood/plasma samples thanks to the funding of plasma stabilising tubes by Les Amis de l’IJB. Qualitative and quantitative analysis of tumour DNA in plasma.

Project 5

Analysis of intra- and peritumoral inflammatory infiltrate in patients who have undergone surgery for hepatocellular carcinoma after intra-arterial radio-embolization. 

Project 6

CEA and ctDNA, post-surgery prognostic factors of primary and hepatic metastatic colorectal cancers.

Our team

Pathologists
- Pr D. Larsimont, (Head of Department)
  Tel : + 32 (0)2 541 31 15
- Dr M. Chintinne (Molecular Biology and Sequencing)
  Tel : + 32 (0)2 541 33 13
- Dr N. de Saint Aubain (immunohistochemistry)
  Tel :+ 32 (0)2 541 31 19
- Dr R. de Wind (Cytology)
  Tel :+ 32 (0)2 541 30 34
- Dr D. d’Olne, Consultant
  Tel :+ 32 (0)2 541 33 13
- Dr M. Gomez Galdon (Macroscopy)
  Tel :+ 32 (0)2 541 33 13
- Dr P. Heimann (Cytogenetic)
  Tel :+ 32 (0)2 541 31 44
- Dr N. Sirtaine (Histology)
  Tel :+ 32 (0)2 541 31 19
- Dr A. Theunis, Consultant
  Tel :+ 32 (0)2 541 31 19
- Prof. P. Demetter (Head of Clinic)
  Tel : + 32 (0)2 541 36 98
- Dr L. Verset (Head of Clinic ajunct)
  Tel : + 32 (0)2 541 33 13
- Dr S. Kacar, PG
  Tel :+ 32 (0)2 541 34 93
- Dr R Dehon, PG
  Tel : + 32 (0)2 541 34 93

Secretariat 
- Permanence (Tel : + 32 (0)2 541 73 23)
- Patricia Hoffman, Secretary
  Tel : + 32 (0)2 541 31 05

Quality Cell
- Ioanna Laïos  
  Tel : + 32 (0)2 541 73 10
- Françoise Roy  
  Tel : + 32 (0)2 541 33 94

Clinical Studies
- Dr Sc L. Craciun, Coordinator
  Tel :+ 32 (0)2 541 72 16

Tumour bank
Dr Sc L. Craciun, Coordinator
A. Spinette

 Scientific publications

HIV virological failure in a patient with human T-lymphotropic virus type 1-associated leukemia.

Authors : Nasreddine R, de Wind R, De Wit S, Martin C
Year : 2019
Journal : AIDS
Volume : 33
Pages : 159-160

FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer.

Authors : De Silva P, Garaud S, Solinas C, de Wind A, Van den Eyden G, Jose V, Gu-Trantien C, Migliori E, Boisson A, Naveaux C, Duvillier H, Craciun L, Larsimont D, Piccart-Gebhart M, Willard-Gallo K
Year : 2019
Journal : EBioMedicine
Volume : 39
Pages : 226-238

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.

Authors : Loi S, Drubay D, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci MV, Badve S, Demaria S, Gray R, Munzone E, Lemonnier J, Sotiriou C, Piccart-Gebhart M, Kellokumpu-Lehtinen PL, Vingiani A, Gray K, Andre F, Denkert C, Salgado R, Michiels S
Year : 2019
Journal : J Clin Oncol
Pages : JCO1801010

The circular RNome of primary breast cancer.

Authors : Smid M, Wilting S, Uhr K, Rodriguez-Gonzalez G, de Weerd V, Prager-Van der Smissen W, van der Vlugt-Daane M, van Galen A, Nik-Zainal S, Butler A, Martin S, Davies H, Staaf J, van de Vijver M, Richardson A, Macgrogan G, Salgado R, Van den Eynden G, Purdie C, Thompson A, Caldas C, Span P, Sweep F, Simpson P, Lakhani S, Van Laere S, Desmedt C, Paradiso A, Eyfjord J, Broeks A, Vincent-Solomon A, Futreal A, Knappskog S, King T, Viari A, Børresen-Dale AL, Stunnenberg H, Stratton M, Foekens J, Sieuwerts A, Martens J
Year : 2019
Journal : Genome Res

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients.

Authors : Chi VLD, Garaud S, De Silva P, Thibaud V, Stamatopoulos B, Berehad M, Gu-Trantien C, Krayem M, Duvillier H, Lodewyckx JN, Willard-Gallo K, Sibille C, Bron D
Year : 2019
Journal : BMC Cancer
Volume : 19
Pages : 81

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