336 clinical trials
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Body (indexed field) | Identifiant (ID) | ||||||||||
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22672 | >=65 years old or, 18 to 64 years old and have at least 1 of the following: 1) CIRS score >6 or 2) Creatinine clearance estimated <70 mL/min - At least one lymph node >1.5 cm by CT - Absence of del 17p or TP53 mutation |
Dominique Bron | LLC | Janssen | GLOW | Trial closed for recruitment | Randomized, Open-label, Phase 3 study of the Combination of Ibrutinib plus Venetoclax versus Chlorambucil plus Obinutuzumab for the First-line Treatment of Subjects with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) | dominique.bron@hubruxelles.be | 3 | 3 | |
22666 | RECIST v1.1 | Ahmad Hussein Awada | Multiple | Genoscience Pharma | GNS561-CL-I-Q-0211 | Trial closed for recruitment | New Title: Phase 1/2a study to evaluate the safety, activity, and pharmacokinetics of escalating doses of GNS561 in patients with primary or secondary liver cancer. (Old Title: Phase 1/2a study to evaluate the safety, activity, and pharmacokinetics of escalating doses of GNS561 in patients with primary liver cancer) |
ahmad.awada@hubruxelles.be | 1 | 1 | |
22816 | HER 2-/HR+ | Ahmad Hussein Awada | Breast | Genentech | GO 28509 | Trial closed | GO 28509 A phase II, randomized study of paclitaxel with GDC-0941 versus paclitaxel with placebo in patients with locally recurrent or metastatic breast cancer | ahmad.awada@hubruxelles.be | 2 | 2 | |
22764 | any line | Ahmad Hussein Awada | Multiple | Genentech-Roche | GO29674 | Trial closed | A Phase Ib, Open-Label, Dose-escalation Study of the safety and Pharmacokinetics of MOXR0916 and MPDL3280A in Patients with Locally Advanced or Metastatic Solid Tumors | ahmad.awada@hubruxelles.be | 1 | 1 | |
28490 | Thierry Berghmans | Lung | Roche | GO41892 - (CONTACT-01) | Trial closed for recruitment | A phase III, multicenter, randomized, open-label, controlled study to evaluate the efficacy, safety, and pharmacokinetics of tezolizumab given in combination with cabozantinib versus docetaxel monotherapy in patients with metastatic non-small cell lung cancer previously treated with an anti-PD-L1/PD-1 antibody and platinum-containing chemotherapy | 3 | 3 | |||
29413 | blood and bone marrow exploration mandatory before steroids prephase /ALL B Phi negative, ALL B Phi positive, and ALL T eligible | Sebastian Wittnebel | Acute leukemia | APHP | GRAALL-2014 trial | Trial closed | Multicenter trial for the treatment of Acute Lymhoblastic Leukemia (ALL) in younger adults (18-59 years) (GRAALL-2014 trial) | Sebastian.Wittnebel@hubruxelles.be | 2/3 | 2 | |
28537 | Triple negative | Ahmad Hussein Awada | Breast | Erytech | GRASPA-TNBC-2018-02 | Trial closed | A Randomized Phase 2/3 Study of Eryaspase in Combination with Gemcitabine and Carboplatin Chemotherapy versus Chemotherapy Alone As First-Line Treatment in Patients with Metastatic or Locally Recurrent Triple-Negative Breast Cancer | ahmad.awada@hubruxelles.be | 2/3 | 2 | |
28624 | 1. moderate or severe cGVHD per NIH Consensus Criteria 2. KPS score > 60%. 3. Evidence of myeloid and platelet engraftment, that is, ANC > 1.0 × 10e9/L and platelet count > 50 × 10e9/L. 4. Has not received more than 3 days/72 hours of systemic corticoster |
Sebastian Wittnebel | NA | Incyte Corporate | GRAVITAS-309 | Trial closed | A Phase 2/3 Study of Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease (GRAVITAS-309) | Sebastian.Wittnebel@hubruxelles.be | 2/3 | 2 | |
22646 | no suitable HLA-matched sibling or unrelated donor / no prior allogeneic stem cell transplantation/ AML, ALL or MDS | Philippe Lewalle | Multiple | Kiadis Pharma | HATCY study | Trial closed | A Phase III, multicenter, randomized controlled study to compare safety and efficacy of a haploidentical HSCT and adjunctive treatment with ATIR101, a T-lymphocyte enriched leukocyte preparation depleted ex vivo of host alloreactive T-cells, versus a haploidentical HSCT with post-transplant cyclophosphamide in patients with a hematologic malignancy | philippe.lewalle@hubruxelles.be | 3 | 3 | |
28578 | Andrea Gombos | Breast | Seagen | HER2CLIMB-02 | Trial closed for recruitment | Randomized, double-blind, Phase III Trial of tucatinib or Placebo in combination with ado-trastuzumab emtansine (T-DM1) for subjects with unresectable locally-advanced or metastatic HER2+ breast cancer (HER2CLIMB-02) | accueil.oncologie@hubruxelles.be | 3 | 3 | ||
28584 | IDH1 or IDH2 +, fit for standard chemotherapy | Sebastian Wittnebel | Acute leukemia | Hovon | HOVON 150 AML/ AMLSG 29-18 | Trial open for recruitment | A phase 3, multicenter, double-blind, randomized, placebo-controlled study of ivosidenib or enasidenib in combination with induction therapy and consolidation therapy followed by maintenance therapy in patients with newly diagnosed acute myeloid leukemia or myelodysplastic syndrome with excess blasts-2, with an IDH1 or IDH2 mutation, respectively, eligible for intensive chemotherapy (HOVON 150 AML/ AMLSG 29-18) | Sebastian.Wittnebel@hubruxelles.be | 3 | 3 | |
29135 | Presence of the FLT3 mutation | Adriano Salaroli | Acute leukemia | Hovon | HOVON 156 AML / AMLSG 28-18 | Trial closed for recruitment | A phase 3, multicenter, open-label, randomized, study of gilteritinib versus midostaurin in combination with induction and consolidation therapy followed by one-year maintenance in patients with newly diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic syndromes with excess blasts-2 (MDS-EB2) with FLT3 mutations eligible for intensive chemotherapy | adriano.salaroli@hubruxelles.be | 3 | 3 | |
29290 | Angela Loizidou | Bordet | I-SPARC | Trial closed | Immune response in patients with cancer undergoing vaccination against SARS-CoV-2 (I-SPARC; IJB-COVID-001) | angela.loizidou@hubruxelles.be | 2 | 2 | |||
22754 | Brain metastasis | Ahmad Hussein Awada | Multiple | Lilly | I3Y-MC-JPBO | Trial closed | A phase II study of Abemaciclib in patients with brain metastases secondary to hormone receptor positive breast cancer, non-small cell lung cancer, or melanoma | ahmad.awada@hubruxelles.be | 2 | 2 |