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Laboratory of Oncology and Experimental Surgery (LOCE)

Description

The Laboratory of Oncology and Experimental Surgery (LOCE) is a laboratory at the Institut Bordet recognised by the ULB Faculty of Medicine. It specialises in research into malignant melanoma and pigment cells in general. It combines fundamental research with preclinical and translational research. The LOCE has a self-contained cell culture unit which has established more than 150 primary lines and cultures of normal and tumour cells (mainly melanomas) and adheres to a rigorous quality control programme. The LOCE shares its cell cultures with some 80 research teams around the world.

Research projects

Project 1

EXPLORATION DE L’EFFET RADIOSENSIBILISATEUR DES MÉDICAMENTS CIBLÉS AINSI QUE LEURS COMBINAISONS UTILISÉS DANS LE MÉLANOME POUR AMÉLIORER LA SENSIBILITÉ DES TUMEURS À LA RADIOTHÉRAPIE.

Project 2

PROFILAGE DU KINOME COMME OUTIL PRÉDICTIF DE L’INIHIBITION DES MAPK DANS LE MÉLANOME ET COMME UNE NOUVELLE APPROCHE POUR ÉTUDIER LES MÉCANISMES DE RÉSISTANCE INTRINSÈQUE ET ACQUISE

Project 3

NOUVELLES ASSOCIATIONS MÉDICAMENTEUSES POUR TRAITER LE MÉLANOME MUQUEUX CKIT MUTÉ.

Project 4

LES PROHIBITINES (PHBS) : NOUVELLES CIBLES THÉRAPEUTIQUES POTENTIELLES DANS LE MÉLANOME.

Project 5

NOUVEAUX MARQUEURS PRONOSTIQUES ET DE PROGRESSION AU NIVEAU DES MÉTASTASES DU MÉLANOME.

The team

Head of Unit
Ghanem E. Ghanem

Researchers
Fabrice Journé
Mohammad Krayem
Ahmad Najem
Renato Morandini

PhD students  
Malak Sabbah

Cell Culture Unit
Isabelle Borsu
Marie-Jeanne Gebski

Laboratory Technicians
Philippe Mersch
Marie-Lydie Pelgrims
Lamine Mihoub
Sebahat Yildirim

Data Manager
Laïla Berdouz

Administrative Assistance
Christiane Meunier
Arlinda Rahmani

 Scientific publications

Involvement of HPV Infection in the Release of Macrophage Migration Inhibitory Factor in Head and Neck Squamous Cell Carcinoma.

Authors : Kindt N, Descamps G, Lechien JR, Remmelink M, Colet JM, Wattiez R, Berchem G, Journe F, Saussez S
Year : 2019
Journal : J Clin Med
Volume : 8

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients.

Authors : Chi VLD, Garaud S, De Silva P, Thibaud V, Stamatopoulos B, Berehad M, Gu-Trantien C, Krayem M, Duvillier H, Lodewyckx JN, Willard-Gallo K, Sibille C, Bron D
Year : 2019
Journal : BMC Cancer
Volume : 19
Pages : 81

Immunohematology Mesenchymal Stromal Cell-based Therapy: From Research to Clinic.

Authors : Najar M, Krayem M, Meuleman N, Bron D, Hélène B, Lagneaux L
Year : 2018
Journal : Appl Immunohistochem Mol Morphol
Volume : 26(3)
Pages : e26-e43

Insights into inflammatory priming of mesenchymal stromal cells: functional biological impacts.

Authors : Najar M, Krayem M, Merimi M, Burny A, Meuleman N, Bron D, Raicevic G, Lagneaux L
Year : 2018
Journal : Inflamm Res
Volume : 67(6)
Pages : 467-477

High infiltration of CD68+ macrophages is associated with poor prognoses of head and neck squamous cell carcinoma patients and is influenced by human papillomavirus.

Authors : Seminerio I, Kindt N, Descamps G, Bellier J, Lechien JR, Mat Q, Pottier C, Journe F, Saussez S
Year : 2018
Journal : Oncotarget
Volume : 9
Pages : 11046-11059

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