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Laboratory of Oncology and Experimental Surgery (LOCE)

Description

The Laboratory of Oncology and Experimental Surgery (LOCE) is a laboratory at the Institut Bordet recognised by the ULB Faculty of Medicine. It specialises in research into malignant melanoma and pigment cells in general. It combines fundamental research with preclinical and translational research. The LOCE has a self-contained cell culture unit which has established more than 150 primary lines and cultures of normal and tumour cells (mainly melanomas) and adheres to a rigorous quality control programme. The LOCE shares its cell cultures with some 80 research teams around the world.

Research projects

Project 1

EXPLORATION DE L’EFFET RADIOSENSIBILISATEUR DES MÉDICAMENTS CIBLÉS AINSI QUE LEURS COMBINAISONS UTILISÉS DANS LE MÉLANOME POUR AMÉLIORER LA SENSIBILITÉ DES TUMEURS À LA RADIOTHÉRAPIE.

Project 2

PROFILAGE DU KINOME COMME OUTIL PRÉDICTIF DE L’INIHIBITION DES MAPK DANS LE MÉLANOME ET COMME UNE NOUVELLE APPROCHE POUR ÉTUDIER LES MÉCANISMES DE RÉSISTANCE INTRINSÈQUE ET ACQUISE

Project 3

NOUVELLES ASSOCIATIONS MÉDICAMENTEUSES POUR TRAITER LE MÉLANOME MUQUEUX CKIT MUTÉ.

Project 4

LES PROHIBITINES (PHBS) : NOUVELLES CIBLES THÉRAPEUTIQUES POTENTIELLES DANS LE MÉLANOME.

Project 5

NOUVEAUX MARQUEURS PRONOSTIQUES ET DE PROGRESSION AU NIVEAU DES MÉTASTASES DU MÉLANOME.

The team

Direction
- Ahmad Awada (Director)
Fabrice Journe (Associate Director)
Ghanem Ghanem (Past Director)

Head of Unit
Nadège Kindt
- Mohammad Krayem
- Zena Wimana
- Ahmad Najem

Post-Doc Researchers
Renato Morandini
- Pashalina Kehagias

PhD Students
Malak Sabbah
- Laura Soumoy
- Morgane Cogels
- Tycho de Bakker
- Ivan Duran, MD              
- Wendy Delbart

Technicians
Sebahat Yildirim (Technical Manager)
- Isabelle Borsu
- Marie-Jeanne Gebski
- Marie-Lydie Pelgrims
- Philippe Mersch
- Lamine Mihoub
- Régis Van Keymeulen (Secretary)
- Leila Berdouz (Data Manager)

11/03/2022

 Scientific publications

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma.

Authors : Najem A, Soumoy L, Sabbah M, Krayem M, Awada A, Journe F, Ghanem GE
Year : 2022
Journal : Cells
Volume : 11

The Road to Dissemination: The Concept of Oligometastases and the Barriers for Widespread Disease.

Authors : AlGhamdi H, Dhont J, Krayem M, De Bruyn P, Engels B, Van Gestel D, Van den Begin R
Year : 2022
Journal : Cancers (Basel)
Volume : 14

Recent advances in radiosensitivity determinants in melanoma.

Authors : Krayem M, Ghanem GE, Van Gestel D
Year : 2022
Journal : Curr Opin Oncol

Neutrophil-to-lymphocyte ratio as a prognostic marker for head and neck cancer with lung metastasis: a retrospective study.

Authors : Yanni A, Buset T, Bouland C, Loeb I, Lechien JR, Rodriguez A, Journe F, Saussez S, Dequanter D
Year : 2022
Journal : Eur Arch Otorhinolaryngol

Survival and treatment outcome of head and neck cancer patients with pulmonary oligometastases.

Authors : Lardinois I, Dequanter D, Lechien JR, Bouland C, Javadian R, Rodriguez A, Loeb I, Journe F, Saussez S
Year : 2021
Journal : Clin Otolaryngol
Volume : 46
Pages : 311-317