Health problems
Mantle cell lymphoma
Mantle cell lymphoma is a type of cancer that affects the B lymphocytes that are a form of white blood cell. The lymphoma takes its name from the “mantle zone” of the lymph nodes which is where these cells are normally found.
A lymphoma of this type develops when the B lymphocytes undergo genetic modifications that causes them to divide uncontrollably. These abnormal cells then accumulate in the lymph nodes, bone marrow, spleen and sometimes in the blood. This disturbs the normal functioning of the immune system.
The symptoms of mantle cell lymphoma can be very varied and often non-specific, making diagnosis difficult. Common symptoms include
- Swelling of lymph nodes: often painless, generally in the neck, armpits and groin.
- Extreme fatigue: not linked to physical exertion.
- Fever: without apparent cause.
- Abundant night time sweating.
- Inexplicable weight loss.
- Abdominal pain and digestive problems: such as nausea or diarrhoea.
There are a number of stages in a mantle cell lymphoma diagnosis:
- Clinical examination: a doctor can detect swollen lymph nodes during a physical examination.
- Biopsy: removal of a lymph node or of bone marrow for laboratory analysis.
- Blood tests: to check the number of blood cells and evaluate organ function.
- Imaging: a PET scan makes it possible to visualise the lymph nodes and other affected organs.
- Genetic examination: to detect specific anomalies in the lymph cells.
Treatment of mantle cell lymphoma can vary depending on a number of factors, such as age, general state of health and stage of the disease. The treatment options include:
- Chemotherapy: the use of drugs to kill the cancer cells.
- Immunotherapy: strengthening the immune system so that it can combat the cancer more effectively.
- Targeted therapy: drugs that target specific anomalies in the cancer cells.
- Radiotherapy: the use of radiation to destroy the cancer cells.
- Stem cell transplant: after intensive chemotherapy stem cells are transplanted to reconstitute the bone marrow.
The prognosis for mantle cell lymphoma depends on the individual and response to the treatment. Regular follow up is essential to monitor remission and detect any recurrence of the cancer. This includes regular medical consultations, blood tests and imaging examinations.
Mantle cell lymphoma is a complex cancer that requires specialised medical care. Progress in research and treatment offer hope and is improving prospects for patients. If you or a loved one are affected it is essential to keep informed and to cooperate closely with your care team to obtain the best possible care.
Living with lymphoma can be difficult for both the patient and those close to them. Here are some useful resources:
- https://cancer.be/cancer/cancer-du-cerveau/
- https://alwb.be/
- https://www.kanker.nl/kankersoorten/lymfeklierkanker
The psycho-oncological services can provide specialised psychological support.
- https://www.bordet.be/fr/psychooncologie
- https://www.psycho-oncologie.be/
The Jules Bordet Institute is recognised by the European network Eurobloodnet for the diagnosis and use of innovative and personalised treatment for this rare and aggressive form of non-Hodgkin lymphoma.
https://eurobloodnet.eu/disease-groups/63/mantle-cell-lymphoma
Our collaborations permit access to numerous clinical trials.
- https://lymphoma-research-experts.org/
- https://www.bordet.be/fr/search/trials-full
- https://www.european-mcl.net/
Virginie De Wilde
Marie Maerevoet
Fulvio Massaro
Alice Wolfromm
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