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The nuclear medicine department of the Institut Jules Bordet offers patients diagnostic tests of the functional or molecular type, as well as treatments with targeted molecular radiotherapy.  

The diagnostic tests differ from those carried out in the Radiology Department in that they involve the intravenous administration of substances labelled with radioactive isotopes, which specifically make it possible to identify the functionality or characteristic of an organ or of the cancer.

Therapeutic applications in nuclear medicine (often called “molecular radiotherapy”) use the same type of substance (tracer) specifically targeting the cancer tissue, but this substance is labelled with radioactive isotopes which emit therapeutic particles of the beta or alpha type enabling the destruction of the diseased cells.

Research projects

Project 1

Predicting the therapeutic result of 177Lu-octreotate (PRRT) using hybrid imaging in the case of refractory neuroendocrine tumours (LuMen)

Project 2

ETUDE DE LA TOLERABILITÉ ET DE L’EFFICACITÉ DU 177LU-DOTATATE (PRRT) CHEZ LES PATIENTS ATTEINTS DE MYÉLOME MULTIPLE EN RECHUTE ET EXPRIMANT LES RÉCEPTEURS DE SOMATOSTATINE

Project 3

Phase II prospective, multicentre study evaluating the utility of a an HER2-PET/CT combined with an FDG-PET/CT in identifying HER2 negative lesions that will not benefit from a new targeted treatment against HER2 : T-DM1 (ZEPHIR)
  • Project leader(s): Géraldine GebhartPatrick Flamen
  • Collaboration(s): Roche, Belgian and Dutch university hospital and centres  
  • Financing/Support : Roche

Project 4

Selective Internal Radiotherapy (SIRT) of colorectal hepatic metastases: prediction of the response

Project 5

Étude de phase III, multicentrique, internationale, prospective, en ouvert, randomisée évaluant le 177Lu- PSMA-617 dans le traitement de patients atteints d’un cancer de la prostate résistant à la castration métastatique (CPRCm), positif au PSMA et évolutif

Project 6

MOLECULAR BIOMARKERS IN METASTATIC CASTRATE RESISTANT PROSTATE CANCER: PSMA EXPRESSION, METABOLIC ACTIVITY, AND CIRCULATING CELL-FREE DNA.

Our team

Head of Department
Prof Patrick Flamen

The team
Dr Carlos Artigas
Assistant Head of Clinic
Dr Géraldine GebhartAssistant Head of Clinic
Dr Ioannis KarfisAssistant Head of Clinic
Dr Elçin ÖzalpAssistant Head of Clinic
Dr Erwin WoffAssistant Head of Clinic
Dr Ivan Duran Derijckere, Resident

Radiophysicists (Department of Radiophysics
Clémentine Marin, Radiophysicist 
Gwennaëlle Marin, Radiophysicist / PhD Student in Medical Physics
Marie Christiane Yimo-Wadje (Physics control)
Bruno Vanderlinden

Radiopharmacy
Prof Ghanem Ghanem

Zéna Wimana
Maxime Renguet
Adriana De Matos
Sara Coelho

Coordination of radionuclide treatments and thyroid checkups
Marie-Noëlle Gheeraert
Pauwel Thijs 
(thyroid cancer)

CoreLab molecular imaging (ORILAB)
Thomas Guiot, Ing

Research Unit
Zéna Wimana, Radiopharmacy/pre-clinical imaging
Wendy Delbart,
PhD Student/Research Assistant
Loubna Taraji Schiltz, Clinical Study Coordinator
Romain Barbieux, Assistant Clinical Research, Lymphology
Hugo Levillain, PhD Student in Medical Physics

Secretaries
Jessie Toussaint
Alyssa Hammouda (PET-Scan)

 Scientific publications

Unilateral Adrenalectomy Could Be a Valid Option for Primary Nodular Adrenal Disease: Evidence From Twins.

Authors : Kyrilli A, Lytrivi M, Bouquegneau MS, Demetter P, Lucidi V, Garcia C, Moreno-Reyes R, Tabarin A, Corvilain B, Driessens N
Year : 2019
Journal : J Endocr Soc
Volume : 3
Pages : 129-134

Radioembolization with <sup>90</sup>Y Resin Microspheres of Neuroendocrine Liver Metastases: International Multicenter Study on Efficacy and Toxicity.

Authors : Braat AJAT, Kappadath SC, Ahmadzadehfar H, Stothers CL, Frilling A, Deroose CM, Flamen P, Brown DB, Sze DY, Mahvash A, Lam MGEH
Year : 2019
Journal : Cardiovasc Intervent Radiol
Volume : 42
Pages : 413-425

3D Monte Carlo dosimetry of intraoperative electron radiation therapy (IOERT).

Authors : Alhamada H, Simon S, Philippson C, Vandekerkhove C, Jourani Y, Pauly N, VanGestel D, Reynaert N
Year : 2019
Journal : Phys Med
Volume : 57
Pages : 207-214

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials.

Authors : Charette N, Vandeputte C, Ameye L, Bogaert CV, Krygier J, Guiot T, Deleporte A, Delaunoit T, Geboes K, Van Laethem JL, Peeters M, Demolin G, Holbrechts S, Flamen P, Paesmans M, Hendlisz A
Year : 2019
Journal : BMC Cancer
Volume : 19
Pages : 134

68Ga-PSMA PET/CT-based metastasis-directed radiotherapy for oligometastatic prostate cancer recurrence after radical prostatectomy.

Authors : Artigas C, Flamen P, Charlier F, Levillain H, Wimana Z, Diamand R, Albisinni S, Gil T, Velthoven Rv, Peltier A, Gestel DV, Roumeguere T, Otte FX
Year : 2019
Journal : World J Urol

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