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Clinical Cellular Therapy Research Laboratory (LTCC)

Description

The Institut Bordet Clinical Cellular Therapy Research Laboratory (LTCC) is dedicated to fundamental and translational research in the fields of haematology and immunology cellular therapy.

The LTCC’s main objectives concern:

  • study of the interaction between leukaemic cells and their microenvironment;
  • establishment of new prognostic factors;
  • development of new therapeutic strategies.

Within the field of cellular therapy, the LTCC is studying the functional characterisation of mesenchymal stromal cells obtained from different tissues and their manipulation with a view to increasing their therapeutic potential.

Research projects

Project 1

IMPACT OF CHRONIC LYMPHOCYTIC LEUKEMIA-DERIVED EXTRACELLULAR VESICLES ON THE MICROENVIRONMENT IMMUNE LANDSCAPE / IMPACT DES VÉSICULES EXTRACELLULAIRES DÉRIVÉES DE LEUCÉMIE LYMPHOÏDE CHRONIQUE SUR LES CELLULES IMMUNITAIRES DU MICROENVIRONNEMENT

Project 2

Phenotypical Characterization and functional Impact of extracellular vesicles from mesenchymal stromal cells on Chronic Lymphocytic Leukemia B-cells

Project 3

Extracellular vesicles derived from umbilical cord-mesenchymal stromal cells for targeted therapy in pancreatic cancer

Project 4

Immunosuppressive microenvironment in multiple myeloma: role of bone marrow-mesenchymal cell (BM-MSC) glycosylation

Project 5

The use of Adipose Tissue derived Stromal Vascular Fraction in a Platelet-Rich Fibrin scaffold within Medication-Related Osteonecrosis of the Jaw treatment
  • Project leader : Cyril Bouland  
  • Collaboration : Nathalie Meuleman, Isabelle Loeb
  • Funding : Fondation Vésal

Our team

Laboratory head
Laurence Lagneaux, PhD

The team
Basile Stamatopoulos, PhD
Karlien Pieters, laboratory technician
Florian Draguet, PhD student Télévie
Nathan Dubois, PhD student Télévie
Cyril Bouland, MD, PhD student
Florent Corrillon, scientific collaborator

 Scientific publications

Therapeutic Mesenchymal Stem/Stromal Cells: Value, Challenges and Optimization.

Authors : Najar M, Melki R, Khalife F, Lagneaux L, Bouhtit F, Moussa Agha D, Fahmi H, Lewalle P, Fayyad-Kazan M, Merimi M
Year : 2022
Journal : Front Cell Dev Biol
Volume : 9
Pages : 716853

Extracellular vesicle secretion by leukemia cells in vivo promotes CLL progression by hampering antitumor T-cell responses.

Authors : Gargiulo E, Viry E, Morande PE, Largeot A, Gonder S, Xian F, Ioannou N, Benzarti M, Kleine Borgmann FB, Mittelbronn M, Dittmar G, Nazarov PV, Meiser J, Stamatopoulos B, Ramsay AG, Moussay E, Paggetti J
Year : 2022
Journal : Blood Cancer Discov

Fundamental and Applied Advances in Stem Cell Therapeutic Research.

Authors : Merimi M, Rahmani S, Afailal Tribak A, Bouhtit F, Fahmi H, Najar M
Year : 2022
Journal : Cells
Volume : 11

Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia.

Authors : Klintman J, Appleby N, Stamatopoulos B, Ridout K, Eyre TA, Robbe P, Pascua LL, Knight SJL, Dreau H, Cabes M, Popitsch N, Ehinger M, Martín-Subero JI, Campo E, Månsson R, Rossi D, Taylor JC, Vavoulis DV, Schuh A
Year : 2021
Journal : Blood
Volume : 137
Pages : 2800-2816

Immuno-comparative screening of adult-derived human liver stem/progenitor cells for immune-inflammatory-associated molecules.

Authors : Merimi M, Lagneaux L, Lombard CA, Agha DM, Bron D, Lewalle P, Meuleman N, Najimi M, Sokal EM, Najar M
Year : 2021
Journal : Inflamm Res
Volume : 70
Pages : 229-239