Health problems
Cutaneous T cell lymphomas
Cutaneous T cell lymphomas are a rare group of cancers affecting the white blood cells (T lymphocytes) found in the skin. Symptoms can include persistent redness, patches of raised scaly skin, itching or lumps. Mycosis fongoides is the most common form, while Sézary syndrome is a more serious form that not only affects the skin but also presents blood cell anomalies. There are other forms that are even rarer such as cutaneous anaplastic T cell lymphoma.
Treatment of cutaneous T cell lymphomas, which are often difficult to diagnose, requires multidisciplinary expertise. The diagnosis is generally reached after the disease has been developing over several years and following repeated biopsies. This is because of its similarity to such benign diseases as eczema. Skin biopsies are essential for a diagnosis, if necessary coupled with an extension assessment (blood test, imaging) to detect whether the lymph nodes or blood have been affected.
At the Jules Bordet Institute the treatment is provided at a clinic dedicated to cutaneous T cell lymphomas that is staffed by dermatologists, haematologists and specialised pathologists. If the disease is localised, the treatment is in the form of creams, UV or orally administered medicine. In more advanced cases systemic intravenous treatment is recommended. For aggressive or resistant forms, an allogeneic bone marrow transplant can be envisaged if a compatible donor is available.
T cell lymphomas are rare and heterogeneous diseases that affect quality of life and self image. Specialised care by a dermatologist and haematologist working in tandem provides the best approach. It is essential to be well informed and surrounded by an experienced team to adapt the treatment to each situation. Coordination with other specialised centres can also be proposed for access to innovative treatment.
Our centre is committed to working with research groups such as the LYSA (Lymphoma Study Association). We play a key role in clinical research, seeking to answer crucial questions on existing care and treatment and the development of new treatment. We also take part in initiatives for systematic centralised case reviews, thereby guaranteeing a collaborative and expert approach to the diagnosis and treatment of cutaneous T cell lymphomas.
Our centre is recognised as a Eurobloodnet expert centre on this rare form of lymphoma.
Dr Alice Wolfromm (haematologist)
Dr Marie Maerevoet(haematologist)
Dr Marine De Vicq (dermatologist)