Radiotherapy is one of the main treatments for cancer and is used as an independent treatment or in combination with surgery and/or systemic treatment (i.e. chemotherapy). The goal is to cure cancer, to augment the prognosis, or to palliate symptoms.
Radiation therapy has a biological effect on the DNA and the inflammatory status of the tumor. The side effects are decreased by modern techniques that allow to paint the dose more precisely.
The proposed treatment is discussed with the patient at consultation, usually after multidisciplinary discussion. The radiation oncologist follows the patient throughout the radiotherapy treatment and takes part in the follow-up after therapy, in close collaboration with the other health professionals.
The Radiotherapy Department of the Jules Bordet Institute is a reference center, well equipped with radiation oncology equipment and a dedicated specialized team. We treat over 2,300 patients per year for a total of 30,000 treatment sessions in a wide range of cancer pathologies. Each radiation oncologist is specialized in several disease domains. The physics and engineering team is responsible for the treatment plan calculation and the quality assurance, and develops and integrates novel technology into clinical routine. The radiation therapists perform the simulation and the daily patient treatments.
Our equipment and experience allow to offer patients a full range of techniques and to remain at the leading edge of innovation in order to improve the efficacy of the treatment and minimize their toxicities. Examples of equipment and techniques include:
- 4 conventional linear accelerators equipped with surface guiding technology.
- Stereotactic Body Radiation Therapy (SBRT) for lesions in the brain, lung, liver, bones and lymph nodes.
- Deep inspiration breath hold (DIBH) for breast cancer patients, in combination with VMAT when indicated
- Total Body Radiation (TBI)
- Gamma Knife unit (Erasmus Hospital site): Radiosurgery of brain lesions
- Linear accelerator for Intraoperative Radiotherapy (IORT), avoiding postoperative radiotherapy in selected breast cancer patients
- Low dose rate (LDR) prostate brachytherapy (seeds)
- High dose rate (HDR) brachytherapy unit, for treatment of
- Gynaecological cancers (including interstitial brachytherapy)
- Oesophageal cancer
- Pulmonary lesions
In 2020, we joined a worldwide research consortium with the mission to implement an integrated magnetic resonance imaging (MRI) guided radiotherapy system. The Elekta Unity MR-linac is the first machine in the world to combine high field-strength MR imaging with a linear accelerator in a single system, allowing to adapt the treatment on a daily basis and to see the tumor while treating. The MR-linac will be installed at the New Bordet site, and we plan to treat patients with this novel machine in the beginning of 2022.
Our specific research page of the radiotherapy department shows our further research domains and projects.
The Radiotherapy Department of the Jules Bordet Institute is a teaching centre for Radiation Oncologists, medical physicists and radiation technologists in training.
The healthcare staff also participates in the academic teaching of radiotherapy and oncology, master’s degrees in medicine at the ULB university, radioprotection, interuniversity courses and the continued development of doctors, nurses, technologists, etc.
Our dedicated research page provides a more comprehensive overview of our research activities. Below we show some examples of current research projects.
Swall PEG study: Patient reported outcomes in term of swallowing and quality of life after prophylactic versus reactive percutaneous endoscopic gastrostomy tube placement in oropharyngeal cancer patients treated with definitive chemoradiotherapy.
Neo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial.
ProCaLung – The Project on Cancer of the Lung
- Project leaders : Florian Charlier, Luigi Moretti
- Trial sponsor: Belgian College of Physicians for Radiotherapy Centers
- Funding: Belgian College of Physicians for Radiotherapy Centers and “Les Amis de l’Institut Bordet”
- Collaboration: Other ProCaLung Team members: Xavier Geets (Cliniques Universitaires Saint-Luc), Maarten Lambrecht (UZLeuven), Yolande Lievens (UZGent), Vincent Remouchamps (CHU-UCL Namur - Site Ste Elizabeth)
Contribution to the study of stereotaxic radiotherapy and its immunomodulatory effect in the treatment of pancreatic cancers.
- Project leaders : Bouchart Christelle, Luigi Moretti
- Trial sponsor : Institut Jules Bordet
- Funding : « Fonds de la Recherche Scientifique – FNRS », « Les Amis de l’Institut Bordet », « Fondation contre le Cancer ».
- Collaboration : Hopital Erasme, Molecular Immunology Lab (MIU, Institut J. Bordet ULB), Laboratory of Medical and Molecular Oncology (LMMO, VUB), CHU Saint-Pierre, CHR Namur and all the hospitals of the ULB network.
Randomized trial to quantify the efficacy of the Safetac® product Mepitel® Film on the prevention of radiodermatitis in the inguinal fold.
- Project leader : Van de Ven Gitte
- Trial sponsor : Institut Jules Bordet
- Funding : Mölnlycke
Head of Department
- Prof Dirk Van Gestel : head and neck tumours, skin tumours, non-malignant tumours, sarcomas, breast tumours.
Medical Physics Department
The radiotherapy physics’ team is part of the central Medical Physics Department of the Institute.
- Prof Nick Reynaert, Head of Medical Physics Department:
- Mr Younes Jourani, Responsible for physics in radiotherapy:
Head of technologists
- Mrs Monica Somoano Tarno
- Dr Imane Ahrouch: breast and gynaecological tumours, brachytherapy
- Dr Sylvie Beauvois : head and neck and skin tumours
- Dr Christelle Bouchart : pancreatic and neurological tumours
- Dr Antoine Desmet : breast and skin tumours, intraoperative radiotherapy and brachytherapy
- Dr Tatiana Dragan : head and neck tumours, sarcomas
- Dr Guillaume Janoray: breast and urological tumours, brachytherapy
- Prof. Philippe Martinive : neurological, digestive and pediatric tumours
- Prof. Luigi Moretti : digestive and thoracic tumours
- Dr François-Xavier Otte : urological tumours
- Dr Catherine Philippson : breast tumours and intraoperative radiotherapy
- Dr Martine Roelandts : thoracic tumours and lymphomas
- Dr Robbe Van den Begin : oligometastatic, urological and digestive tumours
- Prof. Honorary Paul Van Houtte : thoracic and gynecological tumours, non-malignant tumours, brachytherapy
- Dr Alex De Caluwé : Research consultant
- Prof. Philippe Lambin: Research Consultant
Radiation Oncologists in training
- Dr Mathilde Baré
- Dr Sofian Benkhaled
- Dr Florian Charlier
- Dr Thomas Descamps
- Dr Emmanuel Fardeau
- Dr Nicolas Jullian
- Dr Martin Mandelier
- Dr Kaoutar Soussy
- Dr Pauline De Bruyn
- Dr Delavigne Marie-Elise
- Dr Bertrand Donneaux
- Dr Hamza Ghassan
The coordinating nurse in radiotherapy supports the patients in organizing their multidisciplinary care, in the first place for the patients referred by other centers.
- Mrs Ysabelle Houtekens
- Mr John Vercauteren
- Mrs Amaryllis N’Tumba
- Mrs Carine Top
- Mrs Carine Vandevelde
ProCaLung - Peer review in stage III, mediastinal node-positive, non-small-cell lung cancer: How to benchmark clinical practice of nodal target volume definition and delineation in Belgium<sup>☆</sup>.
Authors : Charlier F, Descamps T, Lievens Y, Geets X, Remouchamps V, Lambrecht M, Moretti L
Year : 2022
Journal : Radiother Oncol
Volume : 167
Pages : 57-64
Clinical Outcomes After Proton Beam Therapy for Locally Advanced Non-Small Cell Lung Cancer: Analysis of a Multi-institutional Prospective Registry.
Authors : Jongen A, Charlier F, Baker K, Chang J, Hartsell W, Laramore G, Mohindra P, Moretti L, Redman M, Rosen L, Tsai H, Van Gestel D, Vargas C, Rengan R
Year : 2022
Journal : Adv Radiat Oncol
Volume : 7
Pages : 100767
Recent advances in radiosensitivity determinants in melanoma.
Authors : Krayem M, Ghanem GE, Van Gestel D
Year : 2022
Journal : Curr Opin Oncol
Advanced cutaneous squamous cell carcinoma of the head in two renal transplanted patients treated with cemiplimab.
Authors : Orte Cano C, Van Meerhaeghe T, Tannous J, Lienard D, Van Gestel D, Cuylits N, Luce S, Carlot S, Le Moine A, Aspeslagh S, Del Marmol V
Year : 2022
Journal : J Eur Acad Dermatol Venereol
Volume : 36 Suppl 1
Pages : 53-58
Differential Biological Effects of Dietary Lipids and Irradiation on the Aorta, Aortic Valve, and the Mitral Valve.
Authors : Donis N, Jiang Z, DEmal C, Hulin A, Debuisson M, Dulgheru R, Nguyen ML, Postolache A, Lallemand F, Coucke P, Martinive P, Herzog M, Pamart D, Terrell J, Pincemail J, Drion P, Delvenne P, Nchimi A, Lancellotti P, Oury C
Year : 2022
Journal : Front Cardiovasc Med
Volume : 9
Pages : 839720