Articles scientifiques

Restoring p53 Function in Head and Neck Squamous Cell Carcinoma to Improve Treatments.

Auteurs : de Bakker T, Journe F, Descamps G, Saussez S, Dragan T, Ghanem G, Krayem M, Van Gestel D
Année : 2021
Journal : Front Oncol
Volume : 11
Pages : 799993

Downregulation of the FTO m⁶A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors.

Auteurs : Jeschke J, Collignon E, Al Wardi C, Krayem M, Bizet M, Jia Y, Garaud S, Wimana Z, Calonne E, Hassabi B, Morandini R, Deplus R, Putmans P, Dube G, Singh NK, Koch A, Shostak K, Rizzotto L, Ross RL, Desmedt C, Bareche Y, Rothé F, Lehmann-Che J, Duterque-Coquillaud M, Leroy X, Menschaert G, Teixeira L, Guo M, Limbach PA, Close P, Chariot A, Leucci E, Ghanem G, Yuan BF, Willard-Gallo K, Sotiriou C, Marine JC, Fuks F
Année : 2021
Journal : Nat Cancer
Volume : 2
Pages : 611-628

Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value.

Auteurs : Najem A, Wouters J, Krayem M, Rambow F, Sabbah M, Sales F, Awada A, Aerts S, Journe F, Marine JC, Ghanem GE
Année : 2021
Journal : Front Oncol
Volume : 11
Pages : 780654

Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research.

Auteurs : Cogels MM, Rouas R, Ghanem GE, Martinive P, Awada A, Van Gestel D, Krayem M
Année : 2021
Journal : Front Oncol
Volume : 11
Pages : 784947

Survival and treatment outcome of head and neck cancer patients with pulmonary oligometastases.

Auteurs : Lardinois I, Dequanter D, Lechien JR, Bouland C, Javadian R, Rodriguez A, Loeb I, Journe F, Saussez S
Année : 2021
Journal : Clin Otolaryngol
Volume : 46
Pages : 311-317

Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified c-Kit.

Auteurs : Sabbah M, Krayem M, Najem A, Sales F, Miller W, Del Rincon S, Awada A, Ghanem GE, Journe F
Année : 2021
Journal : Mol Cancer Res
Volume : 19
Pages : 1221-1233

Investigating intrinsic radiosensitivity biomarkers to peptide receptor radionuclide therapy with [¹⁷⁷Lu]Lu-DOTATATE in a panel of cancer cell lines.

Auteurs : Delbart W, Ghanem G, Karfis I, Flamen P, Wimana Z
Année : 2021
Journal : Nucl Med Biol
Volume : 96-97
Pages : 68-79

Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates anti-tumor immune responses.

Auteurs : Huang F, Goncalves C, Bartish M, Rémy-Sarrazin J, Issa ME, Cordeiro B, Guo Q, Emond A, Attias M, Yang W, Plourde D, Su J, Gimeno MG, Zhan Y, Galán A, Rzymski T, Mazan M, Masiejczyk M, Faber J, Khoury E, Benoit A, Gagnon N, Dankort D, Journe F, Ghanem G, Krawczyk CM, Saragovi HU, Piccirillo CA, Sonenberg N, Topisirovic I, Rudd CE, Miller WH Jr, Del Rincón SV
Année : 2021
Journal : J Clin Invest

ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection.

Auteurs : Descamps G, Verset L, Trelcat A, Hopkins C, Lechien JR, Journe F, Saussez S
Année : 2020
Journal : Biology (Basel)
Volume : 9

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma.

Auteurs : Wouters J, Kalender-Atak Z, Minnoye L, Spanier KI, De Waegeneer M, Bravo González-Blas C, Mauduit D, Davie K, Hulselmans G, Najem A, Dewaele M, Pedri D, Rambow F, Makhzami S, Christiaens V, Ceyssens F, Ghanem G, Marine JC, Poovathingal S, Aerts S
Année : 2020
Journal : Nat Cell Biol
Volume : 22
Pages : 986-998

Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms.

Auteurs : Soumoy L, Wells M, Najem A, Krayem M, Ghanem G, Hambye S, Saussez S, Blankert B, Journe F
Année : 2020
Journal : Biology (Basel)
Volume : 9

Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells.

Auteurs : Absil L, Journe F, Larsimont D, Body JJ, Tafforeau L, Nonclercq D
Année : 2020
Journal : BMC Cancer
Volume : 20
Pages : 640

Erratum: Krayem, M., et al. Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance Short Title: Sensitivity Prediction to MAPK Inhibitors in Melanoma. <i>

Auteurs : Krayem M, Aftimos P, Najem A, Hooven TVD, Berg AVD, Hovestad-Bijl L, Wijn R, Hilhorst R, Ruijtenbeek R, Sabbah M, Kerger J, Awada A, Journe F, Ghanem G
Année : 2020
Journal : Cancers (Basel)
Volume : 12

Metabolic Reprogramming in Metastatic Melanoma with Acquired Resistance to Targeted Therapies: Integrative Metabolomic and Proteomic Analysis.

Auteurs : Soumoy L, Schepkens C, Krayem M, Najem A, Tagliatti V, Ghanem G, Saussez S, Colet JM, Journe F
Année : 2020
Journal : Cancers (Basel)
Volume : 12

VCAM-1 Target in Non-Invasive Imaging for the Detection of Atherosclerotic Plaques.

Auteurs : Thayse K, Kindt N, Laurent S, Carlier S
Année : 2020
Journal : Biology (Basel)
Volume : 9

FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma.

Auteurs : Tétu P, Delyon J, André J, Reger de Moura C, Sabbah M, Ghanem G, Battistella M, Mourah S, Lebbé C, Dumaz N
Année : 2020
Journal : Cancers (Basel)
Volume : 12

HPV Involvement in the Tumor Microenvironment and Immune Treatment in Head and Neck Squamous Cell Carcinomas.

Auteurs : Lechien JR, Descamps G, Seminerio I, Furgiuele S, Dequanter D, Mouawad F, Badoual C, Journe F, Saussez S
Année : 2020
Journal : Cancers (Basel)
Volume : 12

Cross-species analysis of enhancer logic using deep learning.

Auteurs : Minnoye L, Taskiran II, Mauduit D, Fazio M, Van Aerschot L, Hulselmans G, Christiaens V, Makhzami S, Seltenhammer M, Karras P, Primot A, Cadieu E, van Rooijen E, Marine JC, Egidy G, Ghanem G, Zon L, Wouters J, Aerts S
Année : 2020
Journal : Genome Res
Volume : 30
Pages : 1815-1834

Kinome Profiling to Predict Sensitivity to MAPK Inhibition in Melanoma and to Provide New Insights into Intrinsic and Acquired Mechanism of Resistance.

Auteurs : Krayem M, Aftimos P, Najem A, van den Hooven T, van den Berg A, Hovestad-Bijl L, de Wijn R, Hilhorst R, Ruijtenbeek R, Sabbah M, Kerger J, Awada A, Journe F, Ghanem G
Année : 2020
Journal : Cancers (Basel)
Volume : 12

Severity of Anosmia as an Early Symptom of COVID-19 Infection May Predict Lasting Loss of Smell.

Auteurs : Lechien JR, Journe F, Hans S, Chiesa-Estomba CM, Mustin V, Beckers E, Vaira LA, De Riu G, Hopkins C, Saussez S
Année : 2020
Journal : Front Med (Lausanne)
Volume : 7
Pages : 582802