Articles scientifiques

A three-gene model to robustly identify breast cancer molecular subtypes.

Auteurs : Haibe-Kains B, Desmedt C, Loi S, Culhane AC, Bontempi G, Quackenbush J, Sotiriou C
Année : 2012
Journal : J. Natl. Cancer Inst.
Volume : 104(4)
Pages : 311-25

The landscape of cancer genes and mutational processes in breast cancer.

Auteurs : Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S, Varela I, Bignell GR, Yates LR, Papaemmanuil E, Beare D, Butler A, Cheverton A, Gamble J, Hinton J, Jia M, Jayakumar A, Jones D, Latimer C, Lau KW, McLaren S, McBride DJ, Menzies A, Mudie L, Raine K, Rad R, Chapman MS, Teague J, Easton D, Langerød A, Lee MT, Shen CY, Tee BT, Huimin BW, Broeks A, Vargas AC, Turashvili G, Martens J, Fatima A, Miron P, Chin SF, Thomas G, Boyault S, Mariani O, Lakhani SR, van de Vijver M, + collaborators (among others :, Desmedt C, Sotiriou C, Stratton MR
Année : 2012
Journal : Nature
Volume : 486(7403)
Pages : 400-4

Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis.

Auteurs : Ignatiadis M, Singhal SK, Desmedt C, Haibe-Kains B, Criscitiello C, Andre F, Loi S, Piccart-Gebhart M, Michiels S, Sotiriou C
Année : 2012
Journal : J. Clin. Oncol.
Volume : 30(16)
Pages : 1996-2004

Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.

Auteurs : Pradeep CR, Zeisel A, Köstler WJ, Lauriola M, Jacob-Hirsch J, Haibe-Kains B, Amariglio N, Ben-Chetrit N, Emde A, Solomonov I, Neufeld G, Piccart-Gebhart M, Sagi I, Sotiriou C, Rechavi G, Domany E, Desmedt C, Yarden Y
Année : 2012
Journal : Oncogene
Volume : 31(31)
Pages : 3569-83

Molecular biology in breast cancer: Should molecular classifiers be assessed by conventional tools or by gene expression arrays?

Auteurs : Fumagalli D, Andre F, Piccart-Gebhart M, Sotiriou C, Desmedt C
Année : 2012
Journal : Crit Rev Oncol Hematol
Volume : 84 supl 1
Pages : e58-69

Next-generation sequencing in breast cancer: first take home messages.

Auteurs : Desmedt C, Voet T, Sotiriou C, Campbell PJ
Année : 2012
Journal : Curr Opin Oncol
Volume : 24(6)
Pages : 597-604

Dissecting the heterogeneity of triple-negative breast cancer.

Auteurs : Metzger-Filho O, Tutt A, de Azambuja E, Saini KS, Viale G, Loi S, Bradbury I, Bliss JM, Azim HA, Ellis P, Di Leo A, Baselga J, Sotiriou C, Piccart-Gebhart M
Année : 2012
Journal : J. Clin. Oncol.
Volume : 30(15)
Pages : 1879-87

Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement.

Auteurs : Guiu S, Michiels S, André F, Cortes J, Denkert C, Di Leo A, Hennessy BT, Sorlie T, Sotiriou C, Turner N, van de Vijver M, Viale G, Loi S, Reis-Filho JS
Année : 2012
Journal : Ann Oncol
Volume : 23
Pages : 2997-3006

Peptides targeting estrogen receptor alpha-potential applications for breast cancer treatment.

Auteurs : Leclercq G, Gallo D, Cossy J, Laïos I, Larsimont D, Laurent G, Jacquot Y
Année : 2011
Journal : Curr. Pharm. Des.
Volume : 17(25)
Pages : 2632-53

HER2-positive circulating tumor cells in breast cancer.

Auteurs : Ignatiadis M, Rothé F, Chaboteaux C, Durbecq V, Rouas G, Criscitiello C, Metallo J, Kheddoumi N, Singhal SK, Michiels S, Veys I, Rossari J, Larsimont D, Carly B, Pestrin M, Bessi S, Buxant F, Liebens F, Piccart-Gebhart M, Sotiriou C
Année : 2011
Journal : PLoS One
Volume : 6(1)
Pages : e15624

Fine tuning of the Van Nuys prognostic index (VNPI) 2003 by integrating the genomic grade index (GGI): new tools for ductal carcinoma in situ (DCIS).

Auteurs : Altintas S, Toussaint J, Durbecq V, Lambein K, Huizing MT, Larsimont D, Van Marck E, Vermorken JB, Tjalma WA, Sotiriou C
Année : 2011
Journal : Breast J
Volume : 17(4)
Pages : 343-51

Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer.

Auteurs : Rothé F, Ignatiadis M, Chaboteaux C, Haibe-Kains B, Kheddoumi N, Majjaj S, Badran B, Fayyad-Kazan H, Desmedt C, Harris AL, Piccart-Gebhart M
Année : 2011
Journal : PLoS One
Volume : 6(6)
Pages : e20980

Gene profiling assay and application: the predictive role in primary therapy.

Auteurs : Fumagalli D, Desmedt C, Ignatiadis M, Loi S, Piccart-Gebhart M, Sotiriou C
Année : 2011
Journal : J. Natl. Cancer Inst. Monographs
Volume : 2011(43)
Pages : 124-7

Largest ever DNA methylation dataset for breast cancer completed.

Auteurs : Dedeurwaerder S, Desmedt C, Calonne E
Année : 2011
Journal : Expert Rev. Mol. Diagn.
Volume : 11(5)
Pages : 470

Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response.

Auteurs : Li Q, Eklund AC, Birkbak NJ, Desmedt C, Haibe-Kains B, Sotiriou C, Symmans WF, Pusztai L, Brunak S, Richardson AL, Szallasi Z
Année : 2011
Journal : BMC Bioinformatics
Volume : 12(null)
Pages : 310

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data.

Auteurs : Di Leo A, Desmedt C, Bartlett JM, Piette F, Ejlertsen B, Pritchard KI, Larsimont D, Poole C, Isola J, Earl H, Mouridsen H
Année : 2011
Journal : Lancet Oncol
Volume : 12(12)
Pages : 1134-42

Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer.

Auteurs : Bedard PL, Singhal SK, Ignatiadis M, Bradbury I, Haibe-Kains B, Desmedt C, Loi S, Evans DB, Michiels S, Dixon JM, Miller WR, Piccart-Gebhart M, Sotiriou C
Année : 2011
Journal : Endocr Relat Cancer
Volume : 18(6)
Pages : 721-30

Multiple-input multiple-output causal strategies for gene selection.

Auteurs : Bontempi G, Haibe-Kains B, Desmedt C, Sotiriou C, Quackenbush J
Année : 2011
Journal : BMC Bioinformatics
Volume : 12(1)
Pages : 458

DNA methylation profiling reveals a predominant immune component in breast cancers.

Auteurs : Dedeurwaerder S, Desmedt C, Calonne E, Singhal SK, Haibe-Kains B, Defrance M, Michiels S, Volkmar M, Deplus R, Luciani J, Lallemand F, Larsimont D, Toussaint J, Haussy S, Rothé F, Rouas G, Metzger O, Majjaj S, Saini K, Putmans P, Hames G, van Baren N, Coulie PG, Piccart-Gebhart M, Sotiriou C, Fuks F
Année : 2011
Journal : EMBO Mol Med
Volume : 3(12)
Pages : 726-41

International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010).

Auteurs : Berruti A, Generali D, Kaufmann M, Puztai L, Curigliano G, Aglietta M, Gianni L, Miller WR, Untch M, Sotiriou C, Daidone M, Conte P, Kennedy D, Damia G, Petronini P, Di Cosimo S, Bruzzi P, Dowsett M, Desmedt C, Mansel RE, Olivetti L, Tondini C, Sapino A, Fenaroli P, Tortora G, Thorne H, Bertolini F, Ferrozzi F, Danova M, Tagliabue E, de Azambuja E, Makris A, Tampellini M, Dontu G
Année : 2011
Journal : J. Natl. Cancer Inst. Monographs
Volume : 2011(43)
Pages : 147-51